Huperserines A-E, Lycopodium alkaloids from Huperzia serrata
Jiang, Wei-Wei1,2; Liu, Fei1,2; Gao, Xiu1,2; He, Juan1; Cheng, Xiao1; Peng, Li-Yan1; Wu, Xing-De1; Zhao, Qin-Shi1
2014-12-01
发表期刊FITOTERAPIA
卷号99页码:72-77
摘要A phytochemical study on Huperzia serrata led to the isolation of four new 5-deoxyfawcettimine-related Lycopodium alkaloids, huperserines A-D (1-4), and one new lycodine-type alkaloid, huperserine E (5). Their structures were elucidated based on spectroscopic data, including 1D and 2D NMR techniques. 5-Carbonyl or 5-hydroxyl group is a typical characteristic of lycopodine- and fawcettimine-type alkaloids. This is the first report of the 5-deoxyfawcettimine type Lycopodium alkaloids. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that huperserine E exhibited moderate anti-AChE activity with an IC50 value of 6.71 mu M. (C) 2014 Elsevier B.V. All rights reserved.
关键词Hupetzia Serrate Lycopodium Alkaloids Huperserines A-e Anti-ache Activity
DOI10.1016/j.fitote.2014.09.005
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000347019000010
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20464
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Jiang, Wei-Wei,Liu, Fei,Gao, Xiu,et al. Huperserines A-E, Lycopodium alkaloids from Huperzia serrata[J]. FITOTERAPIA,2014,99:72-77.
APA Jiang, Wei-Wei.,Liu, Fei.,Gao, Xiu.,He, Juan.,Cheng, Xiao.,...&Zhao, Qin-Shi.(2014).Huperserines A-E, Lycopodium alkaloids from Huperzia serrata.FITOTERAPIA,99,72-77.
MLA Jiang, Wei-Wei,et al."Huperserines A-E, Lycopodium alkaloids from Huperzia serrata".FITOTERAPIA 99(2014):72-77.
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