| Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities | |
Yin, Rong-Hua1,2; Zhao, Zhen-Zhu1,2; Chen, He-Ping1,2; Yin, Xia1,2; Ji, Xu1 ; Dong, Ze-Jun1; Li, Zheng-Hui1; Feng, Tao1; Liu, Ji-Kai1
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| 2014-12-01 | |
| 发表期刊 | PHYTOCHEMISTRY LETTERS
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| 卷号 | 10页码:300-303 |
| 摘要 | Five new tremulane sesquiterpenes (1-5), together with seven known ones (6-12), were isolated from cultures of the fungus Phellinus igniarius. The new compounds were established as 6 beta, 11,12-trihydroxytremul- 1(10)-ene (1), 11,12-dihydroxyl-7 beta-peroxy-hydroxyl-tremul-1(10)-ene (2), 6 beta, 12-dihydroxytremulene (3), 10 beta, 12-dihydroxy-tremulene (4), and 12,15-dihydroxy-tremulene (5) on the basis of their MS and NMR data. Compounds 1-6 were evaluated for their vascular-relaxing activities. In preliminary in vitro assays, at 3 x 10(-4) M, they showed vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 29.9%, 39.9%, 48.5%, 78.7%, 32.3%, and 59.3%, respectively. In addition, compounds 1, 4, and 6 exhibited different levels of vascular-relaxing activities against KCl-induced vasoconstriction with relaxing rates of 31.3%, 57.7%, and 14.0%, as compared with the blank control. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| 关键词 | Phellinus Igniarius Tremulane Sesquiterpenes Vascular-relaxing Activity |
| DOI | 10.1016/j.phytol.2014.10.019 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347915800078 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/20461 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Rong-Hua,Zhao, Zhen-Zhu,Chen, He-Ping,et al. Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities[J]. PHYTOCHEMISTRY LETTERS,2014,10:300-303. |
| APA | Yin, Rong-Hua.,Zhao, Zhen-Zhu.,Chen, He-Ping.,Yin, Xia.,Ji, Xu.,...&Liu, Ji-Kai.(2014).Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities.PHYTOCHEMISTRY LETTERS,10,300-303. |
| MLA | Yin, Rong-Hua,et al."Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities".PHYTOCHEMISTRY LETTERS 10(2014):300-303. |
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