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题名: Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities
作者: Yin, Rong-Hua1, 2; Zhao, Zhen-Zhu1, 2; Chen, He-Ping1, 2; Yin, Xia1, 2; Ji, Xu1; Dong, Ze-Jun1; Li, Zheng-Hui1; Feng, Tao1; Liu, Ji-Kai1
刊名: PHYTOCHEMISTRY LETTERS
出版日期: 2014-12-01
卷号: 10, 页码:300-303
关键词: Phellinus igniarius ; Tremulane sesquiterpenes ; Vascular-relaxing activity
DOI: 10.1016/j.phytol.2014.10.019
文章类型: Article
英文摘要: Five new tremulane sesquiterpenes (1-5), together with seven known ones (6-12), were isolated from cultures of the fungus Phellinus igniarius. The new compounds were established as 6 beta, 11,12-trihydroxytremul- 1(10)-ene (1), 11,12-dihydroxyl-7 beta-peroxy-hydroxyl-tremul-1(10)-ene (2), 6 beta, 12-dihydroxytremulene (3), 10 beta, 12-dihydroxy-tremulene (4), and 12,15-dihydroxy-tremulene (5) on the basis of their MS and NMR data. Compounds 1-6 were evaluated for their vascular-relaxing activities. In preliminary in vitro assays, at 3 x 10(-4) M, they showed vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 29.9%, 39.9%, 48.5%, 78.7%, 32.3%, and 59.3%, respectively. In addition, compounds 1, 4, and 6 exhibited different levels of vascular-relaxing activities against KCl-induced vasoconstriction with relaxing rates of 31.3%, 57.7%, and 14.0%, as compared with the blank control. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: ANTIOXIDANT ; DERIVATIVES
收录类别: SCI
语种: 英语
WOS记录号: WOS:000347915800078
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20461
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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