Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities
Yin, Rong-Hua1,2; Zhao, Zhen-Zhu1,2; Chen, He-Ping1,2; Yin, Xia1,2; Ji, Xu1; Dong, Ze-Jun1; Li, Zheng-Hui1; Feng, Tao1; Liu, Ji-Kai1
2014-12-01
发表期刊PHYTOCHEMISTRY LETTERS
卷号10页码:300-303
摘要Five new tremulane sesquiterpenes (1-5), together with seven known ones (6-12), were isolated from cultures of the fungus Phellinus igniarius. The new compounds were established as 6 beta, 11,12-trihydroxytremul- 1(10)-ene (1), 11,12-dihydroxyl-7 beta-peroxy-hydroxyl-tremul-1(10)-ene (2), 6 beta, 12-dihydroxytremulene (3), 10 beta, 12-dihydroxy-tremulene (4), and 12,15-dihydroxy-tremulene (5) on the basis of their MS and NMR data. Compounds 1-6 were evaluated for their vascular-relaxing activities. In preliminary in vitro assays, at 3 x 10(-4) M, they showed vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 29.9%, 39.9%, 48.5%, 78.7%, 32.3%, and 59.3%, respectively. In addition, compounds 1, 4, and 6 exhibited different levels of vascular-relaxing activities against KCl-induced vasoconstriction with relaxing rates of 31.3%, 57.7%, and 14.0%, as compared with the blank control. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Phellinus Igniarius Tremulane Sesquiterpenes Vascular-relaxing Activity
DOI10.1016/j.phytol.2014.10.019
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000347915800078
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20461
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Yin, Rong-Hua,Zhao, Zhen-Zhu,Chen, He-Ping,et al. Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities[J]. PHYTOCHEMISTRY LETTERS,2014,10:300-303.
APA Yin, Rong-Hua.,Zhao, Zhen-Zhu.,Chen, He-Ping.,Yin, Xia.,Ji, Xu.,...&Liu, Ji-Kai.(2014).Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities.PHYTOCHEMISTRY LETTERS,10,300-303.
MLA Yin, Rong-Hua,et al."Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities".PHYTOCHEMISTRY LETTERS 10(2014):300-303.
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