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题名: New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa
作者: Zhang, Yu1; null(郭伶俐)1; Yang, Guangmei1; Guo, Feng1; null(邸迎彤)1; Li, Shunlin1; Chen, Duozhi1; null(郝小江)1
刊名: FITOTERAPIA
出版日期: 2015
卷号: 100, 页码:150-155
关键词: Tabernaemontana corymbosa ; Bisindole alkaloids ; Tabercorines A-C ; Cytotoxicity
DOI: 10.1016/j.fitote.2014.11.016
文章类型: Article
英文摘要: Ten vobasinyl-ibogan type bisindole alkaloids, including three new ones, tabercorines A-C (1-3), and a new natural product, 17-acetyl-tabemaecorymbosine A (4), were isolated from the twigs and leaves of Tabernaemontana coymbosa. Their structures were elucidated on the basis of spectroscopic data, and the NMR data of 17-acetyl-tabemaecorymbosine A (4) was assigned and reported for the first time. The absolute configurations of 1-4 were determined by CD exciton chirality method. All new compounds were evaluated for in vitro cytotoxicity against various human cancer cell lines. Compounds 1 and 4 showed significant inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: INDOLE ALKALOIDS ; ERVATAMIA-CHINENSIS
收录类别: SCI
语种: 英语
WOS记录号: WOS:000349881300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20431
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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