New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa
Zhang, Yu; Guo, Lingli; Yang, Guangmei; Guo, Feng; Di, Yingtong; Li, Shunlin; Chen, Duozhi; Hao, Xiaojiang
2015
发表期刊FITOTERAPIA
卷号100页码:150-155
摘要Ten vobasinyl-ibogan type bisindole alkaloids, including three new ones, tabercorines A-C (1-3), and a new natural product, 17-acetyl-tabemaecorymbosine A (4), were isolated from the twigs and leaves of Tabernaemontana coymbosa. Their structures were elucidated on the basis of spectroscopic data, and the NMR data of 17-acetyl-tabemaecorymbosine A (4) was assigned and reported for the first time. The absolute configurations of 1-4 were determined by CD exciton chirality method. All new compounds were evaluated for in vitro cytotoxicity against various human cancer cell lines. Compounds 1 and 4 showed significant inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
关键词Tabernaemontana Corymbosa Bisindole Alkaloids Tabercorines A-c Cytotoxicity
DOI10.1016/j.fitote.2014.11.016
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000349881300019
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20431
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Zhang, Yu,Guo, Lingli,Yang, Guangmei,et al. New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa[J]. FITOTERAPIA,2015,100:150-155.
APA Zhang, Yu.,Guo, Lingli.,Yang, Guangmei.,Guo, Feng.,Di, Yingtong.,...&Hao, Xiaojiang.(2015).New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa.FITOTERAPIA,100,150-155.
MLA Zhang, Yu,et al."New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa".FITOTERAPIA 100(2015):150-155.
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