Two C-21- and C-22-terpenoids, salviprzols A (1) and B (2), together with 24 known compounds including 17 diterpenoids (3-19), a triterpenoid (20), and 6 phenolic derivatives (21-26), were isolated from the roots of Salvia przewalskii Maxim. Salviprzols A and B represented a new subtype of C-23-terpenoids featured by an additional 2-oxopropyl moiety at C-12 and a rare gamma-hydroxyl-alpha-methyl-alpha,beta-unsaturated-gamma-lactone ring system. Their structures were elucidated by extensive spectroscopic analyses, and the structure of 2 was confirmed by a single-crystal X-ray diffraction crystallography. The cytotoxic activities of the new isolates were tested. A plausible biosynthetic pathway for 1 and 2 was also proposed. (C) 2014 Elsevier B.V. All rights reserved.
1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resourcese West C, Kunming 650204, Peoples R China 3.Dali Univ, Sch Pharm, Dali 671003, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Wuhan 430000, Peoples R China