Steroidal saponins with induced platelet aggregation activity from the aerial parts of Paris verticillata
Sun, Chang-Li1,2; Ni, Wei1; Yan, Huan1; Liu, Zhen-Hua1; Yang, Lian1; Si, Yong-Ai1; Hua, Yan2; Chen, Chang-Xiang1; He, Li3; Zhao, Jin-Hua1; Liu, Hai-Yang1
2014-12-15
发表期刊STEROIDS
卷号92页码:90-95
摘要In order to utilize and protect the resources of Rhizoma Paridis rationally, we carried out a phytochemical investigation on the non-medicinal (aerial) parts of Paris verticillata that led to the isolation of fifteen steroidal saponins. Among them, three are new spirostanol saponins, named parisverticosides A-C (1-3), as well as one new cholestane glycoside, named parisverticoside D (4). Their structures were elucidated by extensive spectroscopic analysis and acid hydrolysis. The aglycone of compound 1 is a new spirostane and identified as (23S,24S,25S)-spirost-5-en-1 beta,3 beta,23, 24-tetraol. The selected isolates were evaluated for induced platelet aggregation activity and compound 5 showed 62% maximal platelet aggregation rate at the concentration of 300 mu g/mL. (C) 2014 Elsevier Inc. All rights reserved.
关键词Paris Verticillata Liliaceae Steroidal Saponins Parisverticosides A-d Induced Platelet Aggregation Activity
DOI10.1016/j.steroids.2014.09.008
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号WOS:000347134300013
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20412
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southwest Forestry Univ, Coll Forestry, Kunming 650224, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China
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Sun, Chang-Li,Ni, Wei,Yan, Huan,et al. Steroidal saponins with induced platelet aggregation activity from the aerial parts of Paris verticillata[J]. STEROIDS,2014,92:90-95.
APA Sun, Chang-Li.,Ni, Wei.,Yan, Huan.,Liu, Zhen-Hua.,Yang, Lian.,...&Liu, Hai-Yang.(2014).Steroidal saponins with induced platelet aggregation activity from the aerial parts of Paris verticillata.STEROIDS,92,90-95.
MLA Sun, Chang-Li,et al."Steroidal saponins with induced platelet aggregation activity from the aerial parts of Paris verticillata".STEROIDS 92(2014):90-95.
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