Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of isatis indigotica
Liu, Ji-Feng; Jiang, Zhi-Yong; Wang, Rui-Rui; Zheng, Yong-Tang; Chen, Ji-Jun; Zhang, Xue-Mei; Ma, Yun-Bao
2007-10-11
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume9Issue:21Pages:4127-4129
Abstract9 alpha,13 alpha-Dihydroxylisopropylidenylisatisine A (1), which was derived from isatisine A (2) and possessed an unprecedented fused pentacyclic skeleton, was isolated from the leaves of Isatis indigotica Fort. The structure and relative configuration were elucidated on the basis of extensive NMR analyses and finally determined by single-crystal X-ray diffraction. Compound 1 showed moderate anti-HIV-1 activity with EC50 = 37.8 mu M and S1 = 7.98.
KeywordCells
Subject AreaChemistry ; Organic
DOI10.1021/ol701540y
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000249987200011
Citation statistics
Cited Times:103[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2013
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Grad Sch, Joint Lab Anti Viral Nat Med, Kunming Branch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Liu, Ji-Feng,Jiang, Zhi-Yong,Wang, Rui-Rui,et al. Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of isatis indigotica[J]. ORGANIC LETTERS,2007,9(21):4127-4129.
APA Liu, Ji-Feng.,Jiang, Zhi-Yong.,Wang, Rui-Rui.,Zheng, Yong-Tang.,Chen, Ji-Jun.,...&Ma, Yun-Bao.(2007).Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of isatis indigotica.ORGANIC LETTERS,9(21),4127-4129.
MLA Liu, Ji-Feng,et al."Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of isatis indigotica".ORGANIC LETTERS 9.21(2007):4127-4129.
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