Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea
Wang, Yue-Hu; Gao, Suo; Yang, Fu-Mei; Sun, Qian-Yun; Wang, Jun-Song; Liu, Hai-Yang; Li, Chun-Shun; Di, Ying-Tong; Li, Shun-Lin; He, Hong-Ping; Hao, Xiao-Jiang
2007-12-06
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号9期号:25页码:5279-5281
摘要Hostasinine A (1), a benzylphenethylamine alkaloid with an unprecedented skeleton featuring a C-4-C-6 linkage and a nitrone moiety, was isolated from Hosta plantaginea. Its structure was established on the basis of spectroscopic data, and was further confirmed by single-crystal X-ray diffraction. The alkaloid was postulated biogenetically from haemanthidine via N-oxidation and aza-aldol-type condensation and was synthesized biomimetically. The inhibitory activities of 1 on acetylcholinesterase (AM) and two tumor cell lines (K562 and A549) were also evaluated.
关键词Amaryllidaceae Alkaloids Sceletium Alkaloids Acetylcholinesterase Assay Transformation
学科领域Chemistry ; Organic
DOI10.1021/ol702438h
收录类别SCI ; IC ; CCR
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000251313000035
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1945
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Key Lab Chem Nat Prod, Guiyang 550002, Peoples R China
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Wang, Yue-Hu,Gao, Suo,Yang, Fu-Mei,et al. Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea[J]. ORGANIC LETTERS,2007,9(25):5279-5281.
APA Wang, Yue-Hu.,Gao, Suo.,Yang, Fu-Mei.,Sun, Qian-Yun.,Wang, Jun-Song.,...&Hao, Xiao-Jiang.(2007).Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea.ORGANIC LETTERS,9(25),5279-5281.
MLA Wang, Yue-Hu,et al."Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea".ORGANIC LETTERS 9.25(2007):5279-5281.
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