Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea

doi:10.1021/ol702438h

	Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea
	Wang, Yue-Hu; Gao, Suo ; Yang, Fu-Mei ; Sun, Qian-Yun ; Wang, Jun-Song ; Liu, Hai-Yang; Li, Chun-Shun ; Di, Ying-Tong; Li, Shun-Lin ; He, Hong-Ping ; Hao, Xiao-Jiang
	2007-12-06
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	9 期号:25 页码:5279-5281
摘要	Hostasinine A (1), a benzylphenethylamine alkaloid with an unprecedented skeleton featuring a C-4-C-6 linkage and a nitrone moiety, was isolated from Hosta plantaginea. Its structure was established on the basis of spectroscopic data, and was further confirmed by single-crystal X-ray diffraction. The alkaloid was postulated biogenetically from haemanthidine via N-oxidation and aza-aldol-type condensation and was synthesized biomimetically. The inhibitory activities of 1 on acetylcholinesterase (AM) and two tumor cell lines (K562 and A549) were also evaluated.
关键词	Amaryllidaceae Alkaloids Sceletium Alkaloids Acetylcholinesterase Assay Transformation
学科领域	Chemistry ; Organic
DOI	10.1021/ol702438h
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000251313000035
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1945
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Key Lab Chem Nat Prod, Guiyang 550002, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yue-Hu,Gao, Suo,Yang, Fu-Mei,et al. Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea[J]. ORGANIC LETTERS,2007,9(25):5279-5281.
APA	Wang, Yue-Hu.,Gao, Suo.,Yang, Fu-Mei.,Sun, Qian-Yun.,Wang, Jun-Song.,...&Hao, Xiao-Jiang.(2007).Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea.ORGANIC LETTERS,9(25),5279-5281.
MLA	Wang, Yue-Hu,et al."Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea".ORGANIC LETTERS 9.25(2007):5279-5281.

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