| Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity | |
Chen, Jian-Chao1; Zhang, Gao-Hong2,3; Zhang, Zhong-Quan1; Qiu, Ming-Hua1 ; Zheng, Yong-Tang2,3; Yang, Liu-Meng2,3; Yu, Kai-Bei4
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| 2008 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 71期号:1页码:153-155 |
| 摘要 | Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of I was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC = 0.09 mu g/mL) with a selectivity index of 16.7. |
| 关键词 | Panacis-scandens Glycosides Rhizomes |
| 学科领域 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np0704396 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000252629400034 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/1931 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Animal Models & Human Dis Mech, Kunming 650223, Yunan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunan, Peoples R China 4.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jian-Chao,Zhang, Gao-Hong,Zhang, Zhong-Quan,et al. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(1):153-155. |
| APA | Chen, Jian-Chao.,Zhang, Gao-Hong.,Zhang, Zhong-Quan.,Qiu, Ming-Hua.,Zheng, Yong-Tang.,...&Yu, Kai-Bei.(2008).Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.JOURNAL OF NATURAL PRODUCTS,71(1),153-155. |
| MLA | Chen, Jian-Chao,et al."Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity".JOURNAL OF NATURAL PRODUCTS 71.1(2008):153-155. |
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