Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity
Chen, Jian-Chao1; Zhang, Gao-Hong2,3; Zhang, Zhong-Quan1; Qiu, Ming-Hua1; Zheng, Yong-Tang2,3; Yang, Liu-Meng2,3; Yu, Kai-Bei4
2008
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号71期号:1页码:153-155
摘要Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of I was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC = 0.09 mu g/mL) with a selectivity index of 16.7.
关键词Panacis-scandens Glycosides Rhizomes
学科领域Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np0704396
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000252629400034
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1931
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Animal Models & Human Dis Mech, Kunming 650223, Yunan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunan, Peoples R China
4.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China
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Chen, Jian-Chao,Zhang, Gao-Hong,Zhang, Zhong-Quan,et al. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(1):153-155.
APA Chen, Jian-Chao.,Zhang, Gao-Hong.,Zhang, Zhong-Quan.,Qiu, Ming-Hua.,Zheng, Yong-Tang.,...&Yu, Kai-Bei.(2008).Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.JOURNAL OF NATURAL PRODUCTS,71(1),153-155.
MLA Chen, Jian-Chao,et al."Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity".JOURNAL OF NATURAL PRODUCTS 71.1(2008):153-155.
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