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题名: Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity
作者: Chen, Jian-Chao1; Zhang, Gao-Hong2, 3; Zhang, Zhong-Quan1; null(邱明华)1; Zheng, Yong-Tang2, 3; Yang, Liu-Meng2, 3; Yu, Kai-Bei4
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: PANACIS-SCANDENS ; GLYCOSIDES ; RHIZOMES
英文摘要: Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of I was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC = 0.09 mu g/mL) with a selectivity index of 16.7.
出版日期: 2008
卷号: 71, 期号:1, 页码:153-155
DOI标识: 10.1021/np0704396
语种: 英语
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1931
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Animal Models & Human Dis Mech, Kunming 650223, Yunan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunan, Peoples R China
4.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China

Recommended Citation:
Chen, JC; Zhang, GH; Zhang, ZQ; Qiu, MH; Zheng, YT; Yang, LM; Yu, KB.Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity,JOURNAL OF NATURAL PRODUCTS,2008,71(1):153-155
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