Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis
Lai, Yongji1; Xue, Yongbo1; Zhang, Mengke1; Zhang, Jinwen2; Tang, Wei3; Liu, Junjun1; Lei, Liang1; Yan, Juming4; Luo, Zengwei1; Zuo, Jianping3; Li, Yan4; Yao, Guangmin1; Zhang, Yonghui1
2013-12-01
发表期刊PHYTOCHEMISTRY
卷号96页码:378-388
摘要Nine germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety, scapiformolactones A-I (1-9), and one known seco-germacrane sesquiterpenoid, 3,7,11-trimethyldodeca-1,6,9-triene-3,11-diol (10), were isolated from whole plants of Salvia scapiformis Hance. Their structures were elucidated by spectroscopic methods including HR-ESIMS, IR, UV, NMR, and CD, as well as by quantum mechanical calculations and chemical transformations. Structures of compounds 1-3 were also confirmed by single-crystal X-ray diffraction analysis. Six germacrane 6,15-diol derivatives (11-16) were obtained by chemical transformation. Compounds 1-9 and 11-16 were evaluated for their in vitro immunomodulatory effects on T and B cells, as well as their in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Salvia Scapiformis Lamiaceae Germacrane Sesquiterpene Conformation Chemical Transformation Quantum Mechanical Calculation Cytotoxicity Immunomodulatory Activity
资助信息Hubei Key Laboratory Foundation of Natural Medicinal Chemistry and Resource Evaluation; Huazhong University of Science and Technology(2010-3); Fundamental Research Funds for the Central Universities(HUST: 2012QN003); Scientific Research Foundation for the Returned Oversea Chinese Scholars; State Education Ministry of China(2010-1561; Program for New Century Excellent Talents in University; 40th; NCET-2008-0224)
DOI10.1016/j.phytochem.2013.10.003
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000328869500040
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19218
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Lai, Yongji,Xue, Yongbo,Zhang, Mengke,et al. Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis[J]. PHYTOCHEMISTRY,2013,96:378-388.
APA Lai, Yongji.,Xue, Yongbo.,Zhang, Mengke.,Zhang, Jinwen.,Tang, Wei.,...&Zhang, Yonghui.(2013).Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis.PHYTOCHEMISTRY,96,378-388.
MLA Lai, Yongji,et al."Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis".PHYTOCHEMISTRY 96(2013):378-388.
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