Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis
Lai, Yongji1; Xue, Yongbo1; Zhang, Mengke1; Zhang, Jinwen2; Tang, Wei3; Liu, Junjun1; Lei, Liang1; Yan, Juming4; Luo, Zengwei1; Zuo, Jianping3; Li, Yan4; Yao, Guangmin1; Zhang, Yonghui1
2013-12-01
Source PublicationPHYTOCHEMISTRY
Volume96Pages:378-388
AbstractNine germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety, scapiformolactones A-I (1-9), and one known seco-germacrane sesquiterpenoid, 3,7,11-trimethyldodeca-1,6,9-triene-3,11-diol (10), were isolated from whole plants of Salvia scapiformis Hance. Their structures were elucidated by spectroscopic methods including HR-ESIMS, IR, UV, NMR, and CD, as well as by quantum mechanical calculations and chemical transformations. Structures of compounds 1-3 were also confirmed by single-crystal X-ray diffraction analysis. Six germacrane 6,15-diol derivatives (11-16) were obtained by chemical transformation. Compounds 1-9 and 11-16 were evaluated for their in vitro immunomodulatory effects on T and B cells, as well as their in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordSalvia Scapiformis Lamiaceae Germacrane Sesquiterpene Conformation Chemical Transformation Quantum Mechanical Calculation Cytotoxicity Immunomodulatory Activity
DOI10.1016/j.phytochem.2013.10.003
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000328869500040
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/19218
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Lai, Yongji,Xue, Yongbo,Zhang, Mengke,et al. Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis[J]. PHYTOCHEMISTRY,2013,96:378-388.
APA Lai, Yongji.,Xue, Yongbo.,Zhang, Mengke.,Zhang, Jinwen.,Tang, Wei.,...&Zhang, Yonghui.(2013).Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis.PHYTOCHEMISTRY,96,378-388.
MLA Lai, Yongji,et al."Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis".PHYTOCHEMISTRY 96(2013):378-388.
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