Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus

doi:10.1021/np070479+

	Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus
	Yan, Meng-Hong 1,2; Cheng, Pi 1,2; Jiang, Zhi-Yong 1; Ma, Yun-Bao 1; Zhang, Xue-Mei1 ; Zhang, Feng-Xue 3; Yang, Liu-Meng 4; Zheng, Yong-Tang 4; Chen, Ji-Jun1
	2008-05-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	71 期号:5 页码:760-763
摘要	Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of periglaucine A (1) was confirmed by single-crystal X-ray diffraction. Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 mu M in C8166 cells (SI = 45.7 and 18.8), respectively.
关键词	Constituents
学科领域	Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np070479+
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000256180600005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1869
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangzhou Univ Tradit Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Mol Immunopharmacol, Kunming 650223, Yunnam, Peoples R China
推荐引用方式 GB/T 7714	Yan, Meng-Hong,Cheng, Pi,Jiang, Zhi-Yong,et al. Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(5):760-763.
APA	Yan, Meng-Hong.,Cheng, Pi.,Jiang, Zhi-Yong.,Ma, Yun-Bao.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2008).Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus.JOURNAL OF NATURAL PRODUCTS,71(5),760-763.
MLA	Yan, Meng-Hong,et al."Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus".JOURNAL OF NATURAL PRODUCTS 71.5(2008):760-763.

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