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题名: Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus
作者: Yan, Meng-Hong1, 2; Cheng, Pi1, 2; Jiang, Zhi-Yong1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Zhang, Feng-Xue3; Yang, Liu-Meng4; Zheng, Yong-Tang4; null(陈纪军)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: CONSTITUENTS
英文摘要: Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of periglaucine A (1) was confirmed by single-crystal X-ray diffraction. Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 mu M in C8166 cells (SI = 45.7 and 18.8), respectively.
出版日期: 2008-05-01
卷号: 71, 期号:5, 页码:760-763
DOI标识: 10.1021/np070479+
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry; Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1869
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangzhou Univ Tradit Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Mol Immunopharmacol, Kunming 650223, Yunnam, Peoples R China

Recommended Citation:
Yan, MH; Cheng, P; Jiang, ZY; Ma, YB; Zhang, XM; Zhang, FX; Yang, LM; Zheng, YT; Chen, JJ.Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus,JOURNAL OF NATURAL PRODUCTS,2008,71(5):760-763
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