中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation
作者: Zhu, Junlan1, 2; Zhang, Jingjie1; Huang, Haishan1, 2; Li, Jingxia1; Yu, Yonghui1; Jin, Honglei1, 2; Li, Yang1, 2; Deng, Xu3, 4; Gao, Jimin2; null(赵勤实)3, 4; Huang, Chuanshu1
刊名: CANCER PREVENTION RESEARCH
关键词: NATURALLY OCCURRING SUBSTANCES ; MAGNETIC-RESONANCE SPECTROSCOPY ; STEM-BARK ; MELODINUS-HENRYI ; CONFORMATIONAL-ANALYSIS ; (+)-SCHOLARISINE ; MECHANISM ; LEAVES ; SEEDS ; CAMPTOTHECIN ; Indole alkaloids ; Cytotoxicity ; Absolute configuration ; Vinca major
英文摘要: Cheliensisin A (Chel A), as a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been demonstrated to have an inhibition of EGF-induced Cl41 cell transformation via stabilizing p53 protein in a Chk1-dependent manner, suggesting its chemopreventive activity in our previous studies. However, its underlying molecular mechanisms have not been fully characterized yet. In the current study, we found that Chel A treatment could increase c-Jun protein phosphorylation and activation, whereas the inhibition of c-Jun phosphorylation, by ectopic expression of a dominant-negative mutant of c-Jun, TAM67, reversed the Chel A inhibition of EGF-induced cell transformation and impaired Chel A induction of p53 protein and apoptosis. Moreover, our results indicated that Chel A treatment led to a PHLPP downregulation by promoting PHLPP protein degradation. We also found that PHLPP could interact with and bind to c-Jun protein, whereas ectopic PHLPP expression blocked c-Jun activation, p53 protein and apoptotic induction by Chel A, and further reversed the Chel A inhibition of EGF-induced cell transformation. With the findings, we have demonstrated that Chel A treatment promotes a PHLPP protein degradation, which can bind to c-Jun and mediates c-Jun phosphorylation, and further leading to p53 protein induction, apoptotic responses, subsequently resulting in cell transformation inhibition and chemopreventive activity of Chel A. (C)2014 AACR.
出版日期: 2014-12-01
卷号: 7, 期号:12, 页码:1270-1281
语种: 英语
收录类别: SCI
学科分类: Oncology
ISSN号: 1940-6207
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18488
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
zhu2014.pdf(3644KB)期刊论文出版稿开放获取View Download

作者单位: 1.NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA
2.Wenzhou Med Univ, Sch Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou, Zhejiang, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China

Recommended Citation:
Zhu, Junlan,Zhang, Jingjie,Huang, Haishan,et al. Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation[J]. CANCER PREVENTION RESEARCH,2014,7(12):1270-1281.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, Junlan]'s Articles
[Zhang, Jingjie]'s Articles
[Huang, Haishan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, Junlan]‘s Articles
[Zhang, Jingjie]‘s Articles
[Huang, Haishan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: zhu2014.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace