Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii
Hu, Zheng-Xi1; Xue, Yong-Bo1; Bi, Xiao-Bin1; Zhang, Jin-Wen2; Luo, Zeng-Wei1; Li, Xiao-Nian3; Yao, Guang-Min1; Wang, Jian-Ping1; Zhang, Yong-Hui1; Wang,JP (reprint author),Huazhong Univ Sci & Technol,Tongji Med Coll,Sch Pharm,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.; hzx616@126.com; yongboxue@mail.hust.edu.cn; bxbin8353@163.com; tjzhangjinwen@163.com; luozengwei@gmail.com; lixiaonian@mail.kib.ac.cn; gyap@mail.hust.edu.cn; jpwang1001@163.com; zhangyh@mails.tjmu.edu.cn
2014-11-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号12期号:11页码:5563-5575
产权排序第一
摘要Five new compounds, including a benzopyran ribonic glycoside, daldiniside A (1), two isocoumarin ribonic glycosides, daldinisides B (2) and C (3), and two alkaloids, 1-(3-indolyl)-2R,3-dihydroxypropan-1-one (4) and 3-ethyl-2, 5-pyrazinedipropanoic acid (5), along with five known compounds (6-10), were isolated from the EtOAc extract of the marine-associated fungus, Daldinia eschscholzii. Their structures were elucidated by extensive physicochemical and spectroscopic properties, besides comparison with literature data. The absolute configurations of compounds 1-3 were corroborated by chemical transformation, GC analysis and X-ray crystallographic analysis. Meanwhile, the absolute configuration of compound 4 and the planar structure of compound 6 were also determined based on the X-ray diffraction analysis. The cytotoxicity of compounds 1-10, antifungal and anti-HIV activities of compounds 1-5 and the in vitro assay for glucose consumption of compounds 1-3 were done in the anti-diabetic model, whereas none showed obvious activity.
关键词Marine-associated Fungus Daldinia Eschscholzii Secondary Metabolites Hydrolysis Gc Analysis X-ray Diffraction Analysis
资助信息National Natural Science Foundation of China [81225024, 31170334]; National Natural Science Foundation of China [81225024, 31170334]; National Science and Technology Support Program of China [2013BAI11B02]; National Science and Technology Support Program of China [2013BAI11B02]
学科领域Chemistry, Medicinal
DOI10.3390/md12115563
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000345531400012
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18470
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wang,JP (reprint author),Huazhong Univ Sci & Technol,Tongji Med Coll,Sch Pharm,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.; hzx616@126.com; yongboxue@mail.hust.edu.cn; bxbin8353@163.com; tjzhangjinwen@163.com; luozengwei@gmail.com; lixiaonian@mail.kib.ac.cn; gyap@mail.hust.edu.cn; jpwang1001@163.com; zhangyh@mails.tjmu.edu.cn
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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GB/T 7714
Hu, Zheng-Xi,Xue, Yong-Bo,Bi, Xiao-Bin,et al. Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii[J]. MARINE DRUGS,2014,12(11):5563-5575.
APA Hu, Zheng-Xi.,Xue, Yong-Bo.,Bi, Xiao-Bin.,Zhang, Jin-Wen.,Luo, Zeng-Wei.,...&zhangyh@mails.tjmu.edu.cn.(2014).Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii.MARINE DRUGS,12(11),5563-5575.
MLA Hu, Zheng-Xi,et al."Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii".MARINE DRUGS 12.11(2014):5563-5575.
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