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题名: Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii
作者: Hu, Zheng-Xi1; Xue, Yong-Bo1; Bi, Xiao-Bin1; Zhang, Jin-Wen2; Luo, Zeng-Wei1; Li, Xiao-Nian3; Yao, Guang-Min1; Wang, Jian-Ping1; Zhang, Yong-Hui1
刊名: MARINE DRUGS
关键词: marine-associated fungus ; Daldinia eschscholzii ; secondary metabolites ; hydrolysis ; GC analysis ; X-ray diffraction analysis
英文摘要: Five new compounds, including a benzopyran ribonic glycoside, daldiniside A (1), two isocoumarin ribonic glycosides, daldinisides B (2) and C (3), and two alkaloids, 1-(3-indolyl)-2R,3-dihydroxypropan-1-one (4) and 3-ethyl-2, 5-pyrazinedipropanoic acid (5), along with five known compounds (6-10), were isolated from the EtOAc extract of the marine-associated fungus, Daldinia eschscholzii. Their structures were elucidated by extensive physicochemical and spectroscopic properties, besides comparison with literature data. The absolute configurations of compounds 1-3 were corroborated by chemical transformation, GC analysis and X-ray crystallographic analysis. Meanwhile, the absolute configuration of compound 4 and the planar structure of compound 6 were also determined based on the X-ray diffraction analysis. The cytotoxicity of compounds 1-10, antifungal and anti-HIV activities of compounds 1-5 and the in vitro assay for glucose consumption of compounds 1-3 were done in the anti-diabetic model, whereas none showed obvious activity.
出版日期: 2014-11-01
卷号: 12, 期号:11, 页码:5563-5575
DOI标识: 10.3390/md12115563
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal
ISSN号: 1660-3397
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18470
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

Recommended Citation:
Hu,Zheng-Xi;Xue,Yong-Bo;Bi,Xiao-Bin;Zhang,Jin-Wen;Luo,Zeng-Wei;Li,Xiao-Nian;Yao,Guang-Min;Wang,Jian-Ping;Zhang,Yong-Hui.Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii,MARINE DRUGS,2014,70(45):8723-8729
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