Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof | |
Jiang, Shi-Zhi1,2; Lei, Ting1,2; Wei, Kun1; Yang, Yu-Rong1; Yang,YR (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yangyurong@mail.kib.ac.cn | |
2014-11-07 | |
发表期刊 | ORGANIC LETTERS |
ISSN | 1523-7060 |
卷号 | 16期号:21页码:5612-5615 |
摘要 | The collective total synthesis of tetracyclic diquinane Lycopodium alkaloids, (+)-paniculatine, (-)-magellanine, (+)-magellaninone, and two analogues (-)-13-epi-paniculatine and (+)-3-hydroxyl-13-dehydro-paniculatine, has been accomplished. By logic-guided addition of a strategically useful hydroxyl group at C-3 of paniculatine, the formidable tetracyclic core was rapidly synthesized utilizing a site-specific and stereoselective aldol cyclization, thus making the ABD -> ABCD tetracyclic approach to diquinane Lycopodium alkaloids attainable for the first time. |
关键词 | Alstonia-scholaris Neurogenesis Proliferation |
学科领域 | Chemistry, Organic |
DOI | 10.1021/ol502679v |
收录类别 | SCI ; IC |
语种 | 英语 |
WOS记录号 | WOS:000344635200027 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/18468 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | Yang,YR (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yangyurong@mail.kib.ac.cn |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Jiang, Shi-Zhi,Lei, Ting,Wei, Kun,et al. Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof[J]. ORGANIC LETTERS,2014,16(21):5612-5615. |
APA | Jiang, Shi-Zhi,Lei, Ting,Wei, Kun,Yang, Yu-Rong,Yang,YR ,&yangyurong@mail.kib.ac.cn.(2014).Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof.ORGANIC LETTERS,16(21),5612-5615. |
MLA | Jiang, Shi-Zhi,et al."Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof".ORGANIC LETTERS 16.21(2014):5612-5615. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Jiang-2014-Collectiv(356KB) | 开放获取 | CC BY-NC-ND | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论