Polyrhachis dives is consumed as an insect food in some regions of China. In this study, new dopamine derivatives, (+)-polyrhadopamine A (1a) and (-)-polyrhadopamine A (1b), (+)-polyrhadopamine B (2a) and (-)-polyrhadopamine B (2b), and polyrhadopamines C-E (3-5), were isolated from this species. The structures and stereochemistry of these substances were assigned by using spectroscopic and computational methods. Compounds 1a, 1b, 2a, and 2b are dimeric N-acetyldopamine derivatives, 3 is a dopamine analog containing an unusual sulfone group, and 4 and 5 possess a rare benzo[d]thiazole moiety. The functions of these substances as ROCK1/2 inhibitors, neural stem cell (NSCs) proliferation stimulators, immunosuppressive, and anti-inflammatory agents were determined. (C) 2014 Elsevier Ltd. All rights reserved.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China 6.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 7.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100039, Peoples R China
Tang,Jian-Jun ab;Zhang,Li;Jiang,Li-Ping;Di,Lei;Yan,Yong-Ming;Tu,Zheng-Chao;Yang,Cui-Ping;Zuo,Zhi-Li;Hou,Bo;Xia,Hou-Lin;Chen,Yong-Bin;Cheng,Yong-Xian.Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation,TETRAHEDRON,2014,34(23):4355-4366