| Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation | |
Tang, Jian-Jun ab1,2; Zhang, Li3; Jiang, Li-Ping6,7; Di, Lei1; Yan, Yong-Ming1,7; Tu, Zheng-Chao4,5; Yang, Cui-Ping6,7; Zuo, Zhi-Li1 ; Hou, Bo1; Xia, Hou-Lin2; Chen, Yong-Bin6,7; Cheng, Yong-Xian1,2; Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; tu_zhengchao@gibh.ac.cn; ybchen@mail.kiz.ac.cn; yxcheng@mail.kib.ac.cn
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| 2014-11-18 | |
| 发表期刊 | TETRAHEDRON
 |
| ISSN | 0040-4020 |
| 卷号 | 70期号:46页码:8852-8857 |
| 摘要 | Polyrhachis dives is consumed as an insect food in some regions of China. In this study, new dopamine derivatives, (+)-polyrhadopamine A (1a) and (-)-polyrhadopamine A (1b), (+)-polyrhadopamine B (2a) and (-)-polyrhadopamine B (2b), and polyrhadopamines C-E (3-5), were isolated from this species. The structures and stereochemistry of these substances were assigned by using spectroscopic and computational methods. Compounds 1a, 1b, 2a, and 2b are dimeric N-acetyldopamine derivatives, 3 is a dopamine analog containing an unusual sulfone group, and 4 and 5 possess a rare benzo[d]thiazole moiety. The functions of these substances as ROCK1/2 inhibitors, neural stem cell (NSCs) proliferation stimulators, immunosuppressive, and anti-inflammatory agents were determined. (C) 2014 Elsevier Ltd. All rights reserved. |
| 关键词 | Polyrhachis Dives Dopamine Derivative Rock1/2 Inhibitors Nscs |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1016/j.tet.2014.09.095 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000344204700007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18461 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; tu_zhengchao@gibh.ac.cn; ybchen@mail.kiz.ac.cn; yxcheng@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China 6.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 7.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Jian-Jun ab,Zhang, Li,Jiang, Li-Ping,et al. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation[J]. TETRAHEDRON,2014,70(46):8852-8857. |
| APA | Tang, Jian-Jun ab.,Zhang, Li.,Jiang, Li-Ping.,Di, Lei.,Yan, Yong-Ming.,...&yxcheng@mail.kib.ac.cn.(2014).Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation.TETRAHEDRON,70(46),8852-8857. |
| MLA | Tang, Jian-Jun ab,et al."Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation".TETRAHEDRON 70.46(2014):8852-8857. |
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