Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation
Tang, Jian-Jun ab1,2; Zhang, Li3; Jiang, Li-Ping6,7; Di, Lei1; Yan, Yong-Ming1,7; Tu, Zheng-Chao4,5; Yang, Cui-Ping6,7; Zuo, Zhi-Li1; Hou, Bo1; Xia, Hou-Lin2; Chen, Yong-Bin6,7; Cheng, Yong-Xian1,2; Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; tu_zhengchao@gibh.ac.cn; ybchen@mail.kiz.ac.cn; yxcheng@mail.kib.ac.cn
2014-11-18
发表期刊TETRAHEDRON
ISSN0040-4020
卷号70期号:46页码:8852-8857
摘要Polyrhachis dives is consumed as an insect food in some regions of China. In this study, new dopamine derivatives, (+)-polyrhadopamine A (1a) and (-)-polyrhadopamine A (1b), (+)-polyrhadopamine B (2a) and (-)-polyrhadopamine B (2b), and polyrhadopamines C-E (3-5), were isolated from this species. The structures and stereochemistry of these substances were assigned by using spectroscopic and computational methods. Compounds 1a, 1b, 2a, and 2b are dimeric N-acetyldopamine derivatives, 3 is a dopamine analog containing an unusual sulfone group, and 4 and 5 possess a rare benzo[d]thiazole moiety. The functions of these substances as ROCK1/2 inhibitors, neural stem cell (NSCs) proliferation stimulators, immunosuppressive, and anti-inflammatory agents were determined. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Polyrhachis Dives Dopamine Derivative Rock1/2 Inhibitors Nscs
资助信息National Natural Science Foundation of China [31171404]; National Natural Science Foundation of China [31171404]; West Light Foundation of the Chinese Academy of Sciences; West Light Foundation of the Chinese Academy of Sciences
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18461
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; tu_zhengchao@gibh.ac.cn; ybchen@mail.kiz.ac.cn; yxcheng@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China
6.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
7.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100039, Peoples R China
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GB/T 7714
Tang, Jian-Jun ab,Zhang, Li,Jiang, Li-Ping,et al. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation[J]. TETRAHEDRON,2014,70(46):8852-8857.
APA Tang, Jian-Jun ab.,Zhang, Li.,Jiang, Li-Ping.,Di, Lei.,Yan, Yong-Ming.,...&yxcheng@mail.kib.ac.cn.(2014).Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation.TETRAHEDRON,70(46),8852-8857.
MLA Tang, Jian-Jun ab,et al."Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation".TETRAHEDRON 70.46(2014):8852-8857.
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