| A New Quinolizidine Alkaloid from Sophora flavescens | |
Wang Lei1,2,3 ; Wu Xing-De3; He Juan3; Li Gen-Tao3; Peng Li-Yan3; Li Yan3; Song Liu-Dong1,2; Zhao Qin-Shi3; Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China.; ynsld@126.com; qinshizhao@mail.kib.ac.cn
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| 2014-11-01 | |
| 发表期刊 | CHEMISTRY OF NATURAL COMPOUNDS
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| ISSN | 0009-3130 |
| 卷号 | 50期号:5页码:876-879 |
| 摘要 | We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae). The constituents were isolated with silica gel column chromatography, semi-preparative HPLC, Sephadex LH-20, and MPLC packed with MCI gel, and their structures were elucidated on the basis of physical characteristics and spectral data. Compounds 1 and 5-8 were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Ten alkaloids were obtained, and their structures were identified as 17 beta-hydroxysophoridine (1), matrine (2), sophocarpine (3), sophoridine (4), isomatrine (5), 7,11-dehydromatrine (6), mamanine (7), sophoranol (8), oxymatrine (9), and oxysophocarpine (10). Compound 1 is a new alkaloid, and compound 7 was isolated from the Sophora flavescens for the first time. None of the compounds were cytotoxic to five human cancer cell lines. |
| 关键词 | Sophora Flavescens Leguminosae Alkaloids Cytotoxicity |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1007/s10600-014-1104-8 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000345139600019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18460 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China.; ynsld@126.com; qinshizhao@mail.kib.ac.cn |
| 作者单位 | 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Lei,Wu Xing-De,He Juan,et al. A New Quinolizidine Alkaloid from Sophora flavescens[J]. CHEMISTRY OF NATURAL COMPOUNDS,2014,50(5):876-879. |
| APA | Wang Lei.,Wu Xing-De.,He Juan.,Li Gen-Tao.,Peng Li-Yan.,...&qinshizhao@mail.kib.ac.cn.(2014).A New Quinolizidine Alkaloid from Sophora flavescens.CHEMISTRY OF NATURAL COMPOUNDS,50(5),876-879. |
| MLA | Wang Lei,et al."A New Quinolizidine Alkaloid from Sophora flavescens".CHEMISTRY OF NATURAL COMPOUNDS 50.5(2014):876-879. |
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