A New Quinolizidine Alkaloid from Sophora flavescens
Wang Lei1,2,3; Wu Xing-De3; He Juan3; Li Gen-Tao3; Peng Li-Yan3; Li Yan3; Song Liu-Dong1,2; Zhao Qin-Shi3; Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China.; ynsld@126.com; qinshizhao@mail.kib.ac.cn
2014-11-01
发表期刊CHEMISTRY OF NATURAL COMPOUNDS
ISSN0009-3130
卷号50期号:5页码:876-879
产权排序第一
摘要We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae). The constituents were isolated with silica gel column chromatography, semi-preparative HPLC, Sephadex LH-20, and MPLC packed with MCI gel, and their structures were elucidated on the basis of physical characteristics and spectral data. Compounds 1 and 5-8 were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Ten alkaloids were obtained, and their structures were identified as 17 beta-hydroxysophoridine (1), matrine (2), sophocarpine (3), sophoridine (4), isomatrine (5), 7,11-dehydromatrine (6), mamanine (7), sophoranol (8), oxymatrine (9), and oxysophocarpine (10). Compound 1 is a new alkaloid, and compound 7 was isolated from the Sophora flavescens for the first time. None of the compounds were cytotoxic to five human cancer cell lines.
关键词Sophora Flavescens Leguminosae Alkaloids Cytotoxicity
资助信息National Natural Science Foundation of China [21272241, 21172223, 31271579, 81322030]; National Natural Science Foundation of China [21272241, 21172223, 31271579, 81322030]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Middle Aged Academic Leaders of Kunming, a project from Center of Cooperative Innovation for South China Medicine of Yunnan Province; National Key Basic Research Program of China [2013CB910900]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Middle Aged Academic Leaders of Kunming, a project from Center of Cooperative Innovation for South China Medicine of Yunnan Province; National Key Basic Research Program of China [2013CB910900]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1007/s10600-014-1104-8
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000345139600019
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18460
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China.; ynsld@126.com; qinshizhao@mail.kib.ac.cn
作者单位1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Wang Lei,Wu Xing-De,He Juan,et al. A New Quinolizidine Alkaloid from Sophora flavescens[J]. CHEMISTRY OF NATURAL COMPOUNDS,2014,50(5):876-879.
APA Wang Lei.,Wu Xing-De.,He Juan.,Li Gen-Tao.,Peng Li-Yan.,...&qinshizhao@mail.kib.ac.cn.(2014).A New Quinolizidine Alkaloid from Sophora flavescens.CHEMISTRY OF NATURAL COMPOUNDS,50(5),876-879.
MLA Wang Lei,et al."A New Quinolizidine Alkaloid from Sophora flavescens".CHEMISTRY OF NATURAL COMPOUNDS 50.5(2014):876-879.
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