A New Quinolizidine Alkaloid from Sophora flavescens
Wang Lei1,2,3; Wu Xing-De3; He Juan3; Li Gen-Tao3; Peng Li-Yan3; Li Yan3; Song Liu-Dong1,2; Zhao Qin-Shi3; Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China.; ynsld@126.com; qinshizhao@mail.kib.ac.cn
2014-11-01
发表期刊CHEMISTRY OF NATURAL COMPOUNDS
ISSN0009-3130
卷号50期号:5页码:876-879
摘要We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae). The constituents were isolated with silica gel column chromatography, semi-preparative HPLC, Sephadex LH-20, and MPLC packed with MCI gel, and their structures were elucidated on the basis of physical characteristics and spectral data. Compounds 1 and 5-8 were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Ten alkaloids were obtained, and their structures were identified as 17 beta-hydroxysophoridine (1), matrine (2), sophocarpine (3), sophoridine (4), isomatrine (5), 7,11-dehydromatrine (6), mamanine (7), sophoranol (8), oxymatrine (9), and oxysophocarpine (10). Compound 1 is a new alkaloid, and compound 7 was isolated from the Sophora flavescens for the first time. None of the compounds were cytotoxic to five human cancer cell lines.
关键词Sophora Flavescens Leguminosae Alkaloids Cytotoxicity
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1007/s10600-014-1104-8
收录类别SCI ; IC
语种英语
WOS记录号WOS:000345139600019
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18460
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China.; ynsld@126.com; qinshizhao@mail.kib.ac.cn
作者单位1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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GB/T 7714
Wang Lei,Wu Xing-De,He Juan,et al. A New Quinolizidine Alkaloid from Sophora flavescens[J]. CHEMISTRY OF NATURAL COMPOUNDS,2014,50(5):876-879.
APA Wang Lei.,Wu Xing-De.,He Juan.,Li Gen-Tao.,Peng Li-Yan.,...&qinshizhao@mail.kib.ac.cn.(2014).A New Quinolizidine Alkaloid from Sophora flavescens.CHEMISTRY OF NATURAL COMPOUNDS,50(5),876-879.
MLA Wang Lei,et al."A New Quinolizidine Alkaloid from Sophora flavescens".CHEMISTRY OF NATURAL COMPOUNDS 50.5(2014):876-879.
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