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题名: A New Quinolizidine Alkaloid from Sophora flavescens
作者: Wang Lei1, 2, 3; Wu Xing-De3; He Juan3; Li Gen-Tao3; Peng Li-Yan3; null(李艳)3; Song Liu-Dong1, 2; null(赵勤实)3
刊名: CHEMISTRY OF NATURAL COMPOUNDS
出版日期: 2014-11-01
卷号: 50, 期号:5, 页码:876-879
关键词: Sophora flavescens ; Leguminosae ; alkaloids ; cytotoxicity
学科分类: Chemistry, Medicinal;Chemistry, Organic
DOI: 10.1007/s10600-014-1104-8
通讯作者: Wang,L (reprint author),Kunming Med Univ,Sch Pharmaceut Sci,Kunming 650500,Peoples R China. ; ynsld@126.com ; qinshizhao@mail.kib.ac.cn
文章类型: Article
英文摘要: We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae). The constituents were isolated with silica gel column chromatography, semi-preparative HPLC, Sephadex LH-20, and MPLC packed with MCI gel, and their structures were elucidated on the basis of physical characteristics and spectral data. Compounds 1 and 5-8 were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Ten alkaloids were obtained, and their structures were identified as 17 beta-hydroxysophoridine (1), matrine (2), sophocarpine (3), sophoridine (4), isomatrine (5), 7,11-dehydromatrine (6), mamanine (7), sophoranol (8), oxymatrine (9), and oxysophocarpine (10). Compound 1 is a new alkaloid, and compound 7 was isolated from the Sophora flavescens for the first time. None of the compounds were cytotoxic to five human cancer cell lines.
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: LUPIN ALKALOIDS
收录类别: SCI ; IC
项目资助者: National Natural Science Foundation of China [21272241, 21172223, 31271579, 81322030] ; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources ; Middle Aged Academic Leaders of Kunming, a project from Center of Cooperative Innovation for South China Medicine of Yunnan Province ; National Key Basic Research Program of China [2013CB910900]
语种: 英语
WOS记录号: WOS:000345139600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18460
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

Recommended Citation:
Wang Lei;Wu Xing-De;He Juan;Li Gen-Tao;Peng Li-Yan;Li Yan;Song Liu-Dong;Zhao Qin-Shi.A New Quinolizidine Alkaloid from Sophora flavescens,CHEMISTRY OF NATURAL COMPOUNDS,2014,70(46):8852-8857
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文件名: Wang-2014-A New Quinolizidine Alkaloid from So.pdf
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