Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook
Xu, Feng-Qing1,2; Xu, Fang-Cheng4; Hou, Bo2; Fan, Wei-Wei2; Zi, Cheng-Ting2; Li, Yan2; Dong, Fa-Wu2; Liu, Yu-Qing2; Sheng, Jun3; Zuo, Zhi-Li2; Hu, Jiang-Miao2; Sheng,J (reprint author),Yunnan Agr Univ,Kunming 650201,Peoples R China.; 623157535@qq.com; zuozhili@mail.kib.ac.cn; hujiangmiao@mail.kib.ac.cn
2014-11-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume24Issue:22Pages:5268-5273
Contribution Rank第二
AbstractThe bioassay-guided chemical investigation of the stems of Dendrobium fimbriatum Hook led to the isolation of seven first reported bibenzyl dimers with a linkage of a methylene moiety, fimbriadimerbi-benzyls A-G (1-7), together with a new dihydrophenanthrene derivative (S)-2,4,5,9-tetrahydroxy-9, 10-dihydrophenanthrene (8) and thirteen known compounds (9-21). The structure of the new compound was established by spectroscopic analysis. Biological evaluation of bibenzyl derivatives against five human cell lines indicated that seven of those compounds exhibited broad-spectrum and cytotoxic activities with IC50 values ranging from 2.2 to 21.2 mu M. Those rare bibenzyl dimers exhibited cytotoxic activities in vitro and the cytotoxicity decreased as the number of oxygen-containing groups in the structure decreases. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordDendrobium Fimbriatum Hook Bibenzyl Dimer Fimbriadimerbibenzyl Cytotoxicity
Subject AreaChemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2014.09.052
Indexed BySCI ; IC
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000343901400028
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18459
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorSheng,J (reprint author),Yunnan Agr Univ,Kunming 650201,Peoples R China.; 623157535@qq.com; zuozhili@mail.kib.ac.cn; hujiangmiao@mail.kib.ac.cn
Affiliation1.Anhui Univ Chinese Med, Hefei 230031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Kunming 650201, Peoples R China
4.Med Univ Anhui, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Xu, Feng-Qing,Xu, Fang-Cheng,Hou, Bo,et al. Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(22):5268-5273.
APA Xu, Feng-Qing.,Xu, Fang-Cheng.,Hou, Bo.,Fan, Wei-Wei.,Zi, Cheng-Ting.,...&hujiangmiao@mail.kib.ac.cn.(2014).Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(22),5268-5273.
MLA Xu, Feng-Qing,et al."Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.22(2014):5268-5273.
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