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题名: Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook
作者: Xu, Feng-Qing1, 2; Xu, Fang-Cheng4; Hou, Bo2; Fan, Wei-Wei2; Zi, Cheng-Ting2; null(李艳)2; Dong, Fa-Wu2; Liu, Yu-Qing2; Sheng, Jun3; Zuo, Zhi-Li2; Hu, Jiang-Miao2
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期: 2014-11-15
卷号: 24, 期号:22, 页码:5268-5273
关键词: Dendrobium fimbriatum Hook ; Bibenzyl dimer ; Fimbriadimerbibenzyl ; Cytotoxicity
学科分类: Chemistry, Medicinal;Chemistry, Organic
DOI: 10.1016/j.bmcl.2014.09.052
通讯作者: Sheng,J (reprint author),Yunnan Agr Univ,Kunming 650201,Peoples R China. ; 623157535@qq.com ; zuozhili@mail.kib.ac.cn ; hujiangmiao@mail.kib.ac.cn
文章类型: Article
英文摘要: The bioassay-guided chemical investigation of the stems of Dendrobium fimbriatum Hook led to the isolation of seven first reported bibenzyl dimers with a linkage of a methylene moiety, fimbriadimerbi-benzyls A-G (1-7), together with a new dihydrophenanthrene derivative (S)-2,4,5,9-tetrahydroxy-9, 10-dihydrophenanthrene (8) and thirteen known compounds (9-21). The structure of the new compound was established by spectroscopic analysis. Biological evaluation of bibenzyl derivatives against five human cell lines indicated that seven of those compounds exhibited broad-spectrum and cytotoxic activities with IC50 values ranging from 2.2 to 21.2 mu M. Those rare bibenzyl dimers exhibited cytotoxic activities in vitro and the cytotoxicity decreased as the number of oxygen-containing groups in the structure decreases. (C) 2014 Elsevier Ltd. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ANTIMUTAGENIC ACTIVITY ; CHEMICAL-COMPONENTS ; ORCHIDACEAE ; NOBILE ; PHENANTHRENES ; GIGANTOL ; PLANTS
收录类别: SCI ; IC
项目资助者: National Program on Key Basic Research Project of China (973 program) [2010CB951704] ; Natural Science Foundation of China [31270434]
语种: 英语
WOS记录号: WOS:000343901400028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18459
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Anhui Univ Chinese Med, Hefei 230031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Kunming 650201, Peoples R China
4.Med Univ Anhui, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China

Recommended Citation:
Xu,Feng-Qing;Xu,Fang-Cheng;Hou,Bo;Fan,Wei-Wei;Zi,Cheng-Ting;Li,Yan;Dong,Fa-Wu;Liu,Yu-Qing;Sheng,Jun;Zuo,Zhi-Li;Hu,Jiang-Miao.Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,51(5):297-304
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文件名: Xu-2014-Cytotoxic bibenzyl dimers from the ste.pdf
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