Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook
Xu, Feng-Qing1,2; Xu, Fang-Cheng4; Hou, Bo2; Fan, Wei-Wei2; Zi, Cheng-Ting2; Li, Yan2; Dong, Fa-Wu2; Liu, Yu-Qing2; Sheng, Jun3; Zuo, Zhi-Li2; Hu, Jiang-Miao2; Sheng,J (reprint author),Yunnan Agr Univ,Kunming 650201,Peoples R China.; 623157535@qq.com; zuozhili@mail.kib.ac.cn; hujiangmiao@mail.kib.ac.cn
2014-11-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号24期号:22页码:5268-5273
产权排序第二
摘要The bioassay-guided chemical investigation of the stems of Dendrobium fimbriatum Hook led to the isolation of seven first reported bibenzyl dimers with a linkage of a methylene moiety, fimbriadimerbi-benzyls A-G (1-7), together with a new dihydrophenanthrene derivative (S)-2,4,5,9-tetrahydroxy-9, 10-dihydrophenanthrene (8) and thirteen known compounds (9-21). The structure of the new compound was established by spectroscopic analysis. Biological evaluation of bibenzyl derivatives against five human cell lines indicated that seven of those compounds exhibited broad-spectrum and cytotoxic activities with IC50 values ranging from 2.2 to 21.2 mu M. Those rare bibenzyl dimers exhibited cytotoxic activities in vitro and the cytotoxicity decreased as the number of oxygen-containing groups in the structure decreases. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Dendrobium Fimbriatum Hook Bibenzyl Dimer Fimbriadimerbibenzyl Cytotoxicity
资助信息National Program on Key Basic Research Project of China (973 program) [2010CB951704]; National Program on Key Basic Research Project of China (973 program) [2010CB951704]; Natural Science Foundation of China [31270434]; Natural Science Foundation of China [31270434]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2014.09.052
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000343901400028
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18459
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Sheng,J (reprint author),Yunnan Agr Univ,Kunming 650201,Peoples R China.; 623157535@qq.com; zuozhili@mail.kib.ac.cn; hujiangmiao@mail.kib.ac.cn
作者单位1.Anhui Univ Chinese Med, Hefei 230031, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Kunming 650201, Peoples R China
4.Med Univ Anhui, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China
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Xu, Feng-Qing,Xu, Fang-Cheng,Hou, Bo,et al. Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(22):5268-5273.
APA Xu, Feng-Qing.,Xu, Fang-Cheng.,Hou, Bo.,Fan, Wei-Wei.,Zi, Cheng-Ting.,...&hujiangmiao@mail.kib.ac.cn.(2014).Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(22),5268-5273.
MLA Xu, Feng-Qing,et al."Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.22(2014):5268-5273.
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