Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 rho g/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.
Royal Golden Jubilee Ph. D. Program under Thailand Research Fund [PHD/0090/2551]
; Humidtropics, a CGIAR Research Program
; Mae Fah Luang University 
; Chinese Academy of Sciences [2013T2S0030]
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Yang,Xing-Wei;Yang,Cui-Ping;Jiang,Li-Ping;Qin,Xu-Jie;Liu,Ya-Ping;Shen,Qiu-Shuo;Chen,Yong-Bin;Luo,Xiao-Dong.Indole Alkaloids with New Skeleton Activating Neural Stem Cells,ORGANIC LETTERS,2014,68(1):159-238