Indole Alkaloids with New Skeleton Activating Neural Stem Cells
Yang, Xing-Wei1,3; Yang, Cui-Ping2; Jiang, Li-Ping2,3; Qin, Xu-Jie1,3; Liu, Ya-Ping1; Shen, Qiu-Shuo2,3; Chen, Yong-Bin2; Luo, Xiao-Dong1; Chen,YB (reprint author),Chinese Acad Sci,Kunming Inst Zool,Key Lab Anim Models & Human Dis Mechanisms,Kunming 650223,Peoples R China.; ybchen@mail.kiz.ac.cn; xdluo@mail.kib.ac.cn
2014-11-07
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号16期号:21页码:5808-5811
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摘要Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 rho g/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.
关键词Enigmatic Relationships Bayesian Phylogenetics Evolutionary History C-4 Photosynthesis Plastid Genomes Grasses Poaceae Tree Selection Woody Bamboos Mixed Models Nuclear Loci Branch Length Chloroplast Phylogenomics Data Partitioning Low Sequence Divergence Sampling Temperate Woody Bamboos
资助信息Royal Golden Jubilee Ph. D. Program under Thailand Research Fund [PHD/0090/2551]; Royal Golden Jubilee Ph. D. Program under Thailand Research Fund [PHD/0090/2551]; Humidtropics, a CGIAR Research Program; Mae Fah Luang University [56101020032]; Chinese Academy of Sciences [2013T2S0030]; Humidtropics, a CGIAR Research Program; Mae Fah Luang University [56101020032]; Chinese Academy of Sciences [2013T2S0030]
学科领域Chemistry, Organic
DOI10.1021/ol5029223
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000344635200077
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18456
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Chen,YB (reprint author),Chinese Acad Sci,Kunming Inst Zool,Key Lab Anim Models & Human Dis Mechanisms,Kunming 650223,Peoples R China.; ybchen@mail.kiz.ac.cn; xdluo@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yang, Xing-Wei,Yang, Cui-Ping,Jiang, Li-Ping,et al. Indole Alkaloids with New Skeleton Activating Neural Stem Cells[J]. ORGANIC LETTERS,2014,16(21):5808-5811.
APA Yang, Xing-Wei.,Yang, Cui-Ping.,Jiang, Li-Ping.,Qin, Xu-Jie.,Liu, Ya-Ping.,...&xdluo@mail.kib.ac.cn.(2014).Indole Alkaloids with New Skeleton Activating Neural Stem Cells.ORGANIC LETTERS,16(21),5808-5811.
MLA Yang, Xing-Wei,et al."Indole Alkaloids with New Skeleton Activating Neural Stem Cells".ORGANIC LETTERS 16.21(2014):5808-5811.
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