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题名: New Cytotoxic Naphthohydroquinone Dimers from Rubia alata
作者: Zhao, Si-Meng1, 2; Wang, Zhe1, 2; Zeng, Guang-Zhi1; Song, Wei-Wu1; Chen, Xiao-Qiang1; Li, Xiao-Nian1; Tan, Ning-Hua1
刊名: ORGANIC LETTERS
出版日期: 2014-11-07
卷号: 16, 期号:21, 页码:5576-5579
关键词: CHIRAL BICYCLIC LACTAMS ; 1ST TOTAL-SYNTHESIS ; ASYMMETRIC-SYNTHESIS ; HELQUIST ANNULATION ; MAGELLANINE-TYPE ; L-PANICULATUM ; (-)-8-DEOXYSERRATININE
学科分类: Chemistry, Organic
DOI: 10.1021/ol502603f
通讯作者: Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; gzh_zeng@mail.kib.ac.cn ; nhtan@mail.kib.ac.cn
文章类型: Article
英文摘要: Two novel naphthohydroquinone dimers with unprecedented skeletons, rubialatins A (1) and B (2), were isolated from the herbal plant Rubia alata together with their precursor, mollugin (3). The structures were elucidated on the basis of NMR spectra and crystal X-ray diffraction. Compound 1, a racemate, was separated by chiral column chromatography, and the absolute configurations of the enantiomers were determined by the computational methods. Cytotoxicity of 1-3 was evaluated as well as the effect on the NF-?B pathway. Compound (+)-1 showed cytotoxicity and could inhibit NF-kappa B pathway. Meanwhile, 2 showed cytotoxicity and a synergistic effect with TNF-alpha on NF-omicron B activation.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: NF-KAPPA-B ; CYCLIC HEXAPEPTIDES ; CORDIFOLIA L ; YUNNANENSIS ; ACTIVATION ; ANTHRAQUINONES ; CYCLOPEPTIDES ; RUBIYUNNANINS ; PEPTIDES
收录类别: SCI ; IC
项目资助者: National Key Basic Research Program of China [2014CB954100] ; Key Research Program of the Chinese Academy of Sciences [KJZD-EW-L07] ; National Natural Science Foundation of China [40830209] ; Science and Technology Program of Yunnan Province [2008GA029]
语种: 英语
WOS记录号: WOS:000344635200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18454
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhao,Si-Meng;Wang,Zhe;Zeng,Guang-Zhi;Song,Wei-Wu;Chen,Xiao-Qiang;Li,Xiao-Nian;Tan,Ning-Hua.New Cytotoxic Naphthohydroquinone Dimers from Rubia alata,ORGANIC LETTERS,2014,80():308-318
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文件名: Zhao-2014-New Cytotoxic Naphthohydroquinone Di.pdf
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