| New Cytotoxic Naphthohydroquinone Dimers from Rubia alata | |
Zhao, Si-Meng1,2; Wang, Zhe1,2 ; Zeng, Guang-Zhi1; Song, Wei-Wu1; Chen, Xiao-Qiang1; Li, Xiao-Nian1; Tan, Ning-Hua1; Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; gzh_zeng@mail.kib.ac.cn; nhtan@mail.kib.ac.cn
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| 2014-11-07 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 16期号:21页码:5576-5579 |
| 摘要 | Two novel naphthohydroquinone dimers with unprecedented skeletons, rubialatins A (1) and B (2), were isolated from the herbal plant Rubia alata together with their precursor, mollugin (3). The structures were elucidated on the basis of NMR spectra and crystal X-ray diffraction. Compound 1, a racemate, was separated by chiral column chromatography, and the absolute configurations of the enantiomers were determined by the computational methods. Cytotoxicity of 1-3 was evaluated as well as the effect on the NF-?B pathway. Compound (+)-1 showed cytotoxicity and could inhibit NF-kappa B pathway. Meanwhile, 2 showed cytotoxicity and a synergistic effect with TNF-alpha on NF-omicron B activation. |
| 关键词 | Chiral Bicyclic Lactams 1st Total-synthesis Asymmetric-synthesis Helquist Annulation Magellanine-type L-paniculatum (-)-8-deoxyserratinine |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/ol502603f |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000344635200018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18454 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; gzh_zeng@mail.kib.ac.cn; nhtan@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Si-Meng,Wang, Zhe,Zeng, Guang-Zhi,et al. New Cytotoxic Naphthohydroquinone Dimers from Rubia alata[J]. ORGANIC LETTERS,2014,16(21):5576-5579. |
| APA | Zhao, Si-Meng.,Wang, Zhe.,Zeng, Guang-Zhi.,Song, Wei-Wu.,Chen, Xiao-Qiang.,...&nhtan@mail.kib.ac.cn.(2014).New Cytotoxic Naphthohydroquinone Dimers from Rubia alata.ORGANIC LETTERS,16(21),5576-5579. |
| MLA | Zhao, Si-Meng,et al."New Cytotoxic Naphthohydroquinone Dimers from Rubia alata".ORGANIC LETTERS 16.21(2014):5576-5579. |
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