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Chemical constituents from Euphorbia stracheyi and their biological activities
Yang, Da-Song1; Peng, Wei-Bing2; Li, Zi-Lei1; Wang, Xue2; Wei, Jian-Guo1; He, Qiu-Xia2; Yang, Yong-Ping1; Liu, Ke-Chun2; Li, Xiao-Li1; Li,XL (reprint author),Chinese Acad Sci,Kunming Inst Bot,Inst Tibetan Plateau Res Kunming,Key Lab Econ Plants & Biotechnol,Germplasm Bank W,Kunming 650201,Peoples R China.; li_xiaoli11@mail.kib.ac.cn
2014-09-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume97Pages:211-218
Contribution Rank第一
AbstractThree new diterpenoids, stracheyioids A-C (1-3), as well as 36 known compounds (4-39) were isolated from the whole plants of Euphorbia stracheyi. Compound 1 was a rare 13-deoxy tigliane diterpenoid and compound 2 was an ingenol diterpenoid characterized by an unique 2Z,4Z-decadienoyl acidic moieties. All the known compounds were isolated from E. stracheyi for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-39 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range 6.64-42.86 mu M. The antiangiogenic activities of the isolated compounds were also evaluated using a zebrafish model. (C) 2014 Elsevier B.V. All rights reserved.
KeywordEuphorbia Stracheyi Euphorbiaceae Diterpenoid Sesquiterpene Cytotoxicity
Subject AreaPharmacology & Pharmacy
DOI10.1016/j.fitote.2014.06.013
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000341346400027
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18407
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorLi,XL (reprint author),Chinese Acad Sci,Kunming Inst Bot,Inst Tibetan Plateau Res Kunming,Key Lab Econ Plants & Biotechnol,Germplasm Bank W,Kunming 650201,Peoples R China.; li_xiaoli11@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Key Lab Econ Plants & Biotechnol,Germplasm Bank W, Kunming 650201, Peoples R China
2.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China
Recommended Citation
GB/T 7714
Yang, Da-Song,Peng, Wei-Bing,Li, Zi-Lei,et al. Chemical constituents from Euphorbia stracheyi and their biological activities[J]. FITOTERAPIA,2014,97:211-218.
APA Yang, Da-Song.,Peng, Wei-Bing.,Li, Zi-Lei.,Wang, Xue.,Wei, Jian-Guo.,...&li_xiaoli11@mail.kib.ac.cn.(2014).Chemical constituents from Euphorbia stracheyi and their biological activities.FITOTERAPIA,97,211-218.
MLA Yang, Da-Song,et al."Chemical constituents from Euphorbia stracheyi and their biological activities".FITOTERAPIA 97(2014):211-218.
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