Chemical constituents from Euphorbia stracheyi and their biological activities
Yang, Da-Song1; Peng, Wei-Bing2; Li, Zi-Lei1; Wang, Xue2; Wei, Jian-Guo1; He, Qiu-Xia2; Yang, Yong-Ping1; Liu, Ke-Chun2; Li, Xiao-Li1; Li,XL (reprint author),Chinese Acad Sci,Kunming Inst Bot,Inst Tibetan Plateau Res Kunming,Key Lab Econ Plants & Biotechnol,Germplasm Bank W,Kunming 650201,Peoples R China.; li_xiaoli11@mail.kib.ac.cn
2014-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号97页码:211-218
产权排序第一
摘要Three new diterpenoids, stracheyioids A-C (1-3), as well as 36 known compounds (4-39) were isolated from the whole plants of Euphorbia stracheyi. Compound 1 was a rare 13-deoxy tigliane diterpenoid and compound 2 was an ingenol diterpenoid characterized by an unique 2Z,4Z-decadienoyl acidic moieties. All the known compounds were isolated from E. stracheyi for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-39 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range 6.64-42.86 mu M. The antiangiogenic activities of the isolated compounds were also evaluated using a zebrafish model. (C) 2014 Elsevier B.V. All rights reserved.
关键词Euphorbia Stracheyi Euphorbiaceae Diterpenoid Sesquiterpene Cytotoxicity
资助信息National Natural Science Foundation of China [31300293, 81202584]; Applied Foundation Research, Yunnan Province [2013FB067]; Basic Research Project of Ministry of Science and Technology of China [2012FY110300]; Major State Basic Research Development Program [2010CB951704]
学科领域Pharmacology & Pharmacy
DOI10.1016/j.fitote.2014.06.013
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000341346400027
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18407
专题资源植物与生物技术所级重点实验室
通讯作者Li,XL (reprint author),Chinese Acad Sci,Kunming Inst Bot,Inst Tibetan Plateau Res Kunming,Key Lab Econ Plants & Biotechnol,Germplasm Bank W,Kunming 650201,Peoples R China.; li_xiaoli11@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Key Lab Econ Plants & Biotechnol,Germplasm Bank W, Kunming 650201, Peoples R China
2.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China
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Yang, Da-Song,Peng, Wei-Bing,Li, Zi-Lei,et al. Chemical constituents from Euphorbia stracheyi and their biological activities[J]. FITOTERAPIA,2014,97:211-218.
APA Yang, Da-Song.,Peng, Wei-Bing.,Li, Zi-Lei.,Wang, Xue.,Wei, Jian-Guo.,...&li_xiaoli11@mail.kib.ac.cn.(2014).Chemical constituents from Euphorbia stracheyi and their biological activities.FITOTERAPIA,97,211-218.
MLA Yang, Da-Song,et al."Chemical constituents from Euphorbia stracheyi and their biological activities".FITOTERAPIA 97(2014):211-218.
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