Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus
Cao, Ming-Ming1,2; Zhang, Yu1; Li, Xiao-Hui1,2; Peng, Zong-Gen3,4; Jiang, Jian-Dong3,4; Gu, Yu-Cheng5; Di, Ying-Tong1; Li, Xiao-Nian1; Chen, Duo-Zhi1; Xia, Cheng-Feng1; He, Hong-Ping1; Li, Shun-Lin1; Hao, Xiao-Jiang; haoxj@mail.kib.ac.cn
2014-09-05
发表期刊JOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
卷号79期号:17页码:7945-7950
摘要Investigation of the alkaloids from Myrioneuron faberi, a plant unique to China, gave four pairs of enantiomers (1-4). (+/-)-beta-Myrifabral A (1) and (+/-)-alpha-myrifabral A (2) formed an inseparable mixture of anomers (duster A), as did (+/-)-beta-myrifabral B (3) and (+/-)-alpha-myrifabral B (4) (cluster B). Their structures were determined by X-ray diffraction and NMR analysis. Compounds 1-4 possessed novel cyclohexane-fused octahydroquinolizine skeletons and represent the first quinolizidine alkaloids from the genus Myrioneuron. The epimers of cluster A (1 and 2) were modified and separated. In vitro, clusters A and B and their derivatives inhibited replication of hepatitis C virus (HCV, IC50 0.9 to 4.7 mu M) with cytotoxicity lower than that of telaprevir.
关键词Biomimetic Synthesis Nutans Nitraramine Skeleton Therapy
资助信息National Natural Science Foundation of China [21372228]; Foundation of Chinese Academy of Sciences; Syngenta postgraduate studentship
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18402
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者haoxj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 10050, Peoples R China
4.Peking Union Med Coll, Beijing 10050, Peoples R China
5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
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Cao, Ming-Ming,Zhang, Yu,Li, Xiao-Hui,et al. Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(17):7945-7950.
APA Cao, Ming-Ming.,Zhang, Yu.,Li, Xiao-Hui.,Peng, Zong-Gen.,Jiang, Jian-Dong.,...&haoxj@mail.kib.ac.cn.(2014).Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus.JOURNAL OF ORGANIC CHEMISTRY,79(17),7945-7950.
MLA Cao, Ming-Ming,et al."Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus".JOURNAL OF ORGANIC CHEMISTRY 79.17(2014):7945-7950.
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