| Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus | |
Cao, Ming-Ming1,2; Zhang, Yu1 ; Li, Xiao-Hui1,2; Peng, Zong-Gen3,4; Jiang, Jian-Dong3,4; Gu, Yu-Cheng5; Di, Ying-Tong1; Li, Xiao-Nian1; Chen, Duo-Zhi1; Xia, Cheng-Feng1; He, Hong-Ping1; Li, Shun-Lin1; Hao, Xiao-Jiang; haoxj@mail.kib.ac.cn
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| 2014-09-05 | |
| 发表期刊 | JOURNAL OF ORGANIC CHEMISTRY
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| ISSN | 0022-3263 |
| 卷号 | 79期号:17页码:7945-7950 |
| 摘要 | Investigation of the alkaloids from Myrioneuron faberi, a plant unique to China, gave four pairs of enantiomers (1-4). (+/-)-beta-Myrifabral A (1) and (+/-)-alpha-myrifabral A (2) formed an inseparable mixture of anomers (duster A), as did (+/-)-beta-myrifabral B (3) and (+/-)-alpha-myrifabral B (4) (cluster B). Their structures were determined by X-ray diffraction and NMR analysis. Compounds 1-4 possessed novel cyclohexane-fused octahydroquinolizine skeletons and represent the first quinolizidine alkaloids from the genus Myrioneuron. The epimers of cluster A (1 and 2) were modified and separated. In vitro, clusters A and B and their derivatives inhibited replication of hepatitis C virus (HCV, IC50 0.9 to 4.7 mu M) with cytotoxicity lower than that of telaprevir. |
| 关键词 | Biomimetic Synthesis Nutans Nitraramine Skeleton Therapy |
| 学科领域 | Chemistry |
| DOI | 10.1021/jo501076x |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000341345400017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18402 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | haoxj@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 10050, Peoples R China 4.Peking Union Med Coll, Beijing 10050, Peoples R China 5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England |
| 推荐引用方式 GB/T 7714 | Cao, Ming-Ming,Zhang, Yu,Li, Xiao-Hui,et al. Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(17):7945-7950. |
| APA | Cao, Ming-Ming.,Zhang, Yu.,Li, Xiao-Hui.,Peng, Zong-Gen.,Jiang, Jian-Dong.,...&haoxj@mail.kib.ac.cn.(2014).Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus.JOURNAL OF ORGANIC CHEMISTRY,79(17),7945-7950. |
| MLA | Cao, Ming-Ming,et al."Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus".JOURNAL OF ORGANIC CHEMISTRY 79.17(2014):7945-7950. |
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