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题名: Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus
作者: Cao, Ming-Ming1, 2; Zhang, Yu1; Li, Xiao-Hui1, 2; Peng, Zong-Gen3, 4; Jiang, Jian-Dong3, 4; Gu, Yu-Cheng5; Di, Ying-Tong1; Li, Xiao-Nian1; Chen, Duo-Zhi1; Xia, Cheng-Feng1; He, Hong-Ping1; Li, Shun-Lin1; null(郝小江)
刊名: JOURNAL OF ORGANIC CHEMISTRY
关键词: BIOMIMETIC SYNTHESIS ; NUTANS ; NITRARAMINE ; SKELETON ; THERAPY
英文摘要: Investigation of the alkaloids from Myrioneuron faberi, a plant unique to China, gave four pairs of enantiomers (1-4). (+/-)-beta-Myrifabral A (1) and (+/-)-alpha-myrifabral A (2) formed an inseparable mixture of anomers (duster A), as did (+/-)-beta-myrifabral B (3) and (+/-)-alpha-myrifabral B (4) (cluster B). Their structures were determined by X-ray diffraction and NMR analysis. Compounds 1-4 possessed novel cyclohexane-fused octahydroquinolizine skeletons and represent the first quinolizidine alkaloids from the genus Myrioneuron. The epimers of cluster A (1 and 2) were modified and separated. In vitro, clusters A and B and their derivatives inhibited replication of hepatitis C virus (HCV, IC50 0.9 to 4.7 mu M) with cytotoxicity lower than that of telaprevir.
出版日期: 2014-09-05
卷号: 79, 期号:17, 页码:7945-7950
DOI标识: 10.1021/jo501076x
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry
ISSN号: 0022-3263
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18402
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 10050, Peoples R China
4.Peking Union Med Coll, Beijing 10050, Peoples R China
5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

Recommended Citation:
Cao,Ming-Ming;Zhang,Yu;Li,Xiao-Hui;Peng,Zong-Gen;Jiang,Jian-Dong;Gu,Yu-Cheng;Di,Ying-Tong;Li,Xiao-Nian;Chen,Duo-Zhi;Xia,Cheng-Feng;He,Hong-Ping;Li,Shun-Lin;Hao,Xiao-Jiang.Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus,JOURNAL OF ORGANIC CHEMISTRY,2014,79(17):7945-7950
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