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题名: Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells
作者: Hou, J-K1, 2; Huang, Y.3; He, W.3; Yan, Z-W3; Fan, L.3; Liu, M-H3; Xiao, W-L4; Sun, H-D4; Chen, G-Q1, 2, 3, 5
刊名: CELL DEATH & DISEASE
出版日期: 2014-09-01
卷号: 5, 页码:e1400
关键词: REACTIVE OXYGEN ; CANCER-CELLS ; SIGNALING PATHWAY ; MECHANISMS ; APOPTOSIS ; ROS ; ROLES ; DEATH ; PRDX1
学科分类: Cell Biology
DOI: 10.1038/cddis.2014.345
通讯作者: Chen,GQ (reprint author),Shandong Jiaotong Univ,Sch Med,Dept Pathophysiol,280 Chong Qing South Rd,Shanghai 200025,Peoples R China. ; huangying@shsmu.edu.cn ; hdsun@mail.kib.ac.cn ; chengq@shsmu.edu.cn
文章类型: Article
英文摘要: Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs for the prevention and treatment of solid tumors. Therefore, it is of significance to explore the potential activities of adenanthin on solid tumor cells. Here, we demonstrate that Prx I protein is essential for the survival of hepatocellular carcinoma (HCC) cells, and adenanthin can kill these malignant liver cells in vitro and xenografts. We also show that the cell death-inducing activity of adenanthin on HCC cells is mediated by the increased reactive oxygen species (ROS) levels. Furthermore, the silencing of Prx I or Prx II significantly enhances the cytotoxic activity of adenanthin on HCC, whereas the ectopic expression of Prx I and Prx II but not their mutants of adenanthin-bound cysteines can rescue adenanthin-induced cytotoxicity in Prxs-silenced HCC cells. Taken together, our results propose that adenanthin targets Prx I/II to kill HCC cells and its therapeutic significance warrants to be further explored in HCC patients.
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: REACTIVE OXYGEN ; CANCER-CELLS ; SIGNALING PATHWAY ; MECHANISMS ; APOPTOSIS ; ROS ; ROLES ; DEATH ; PRDX1
收录类别: SCI
语种: 英语
WOS记录号: WOS:000343162000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18399
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Univ Chinese Acad Sci, SIBS, Inst Hlth Sci, Shanghai, Peoples R China
2.Shandong Jiaotong Univ, Sch Med, Shanghai 200025, Peoples R China
3.Shandong Jiaotong Univ, Sch Med, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis,Chinese Min, Shanghai 200025, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
5.SJTU SM, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China

Recommended Citation:
Hou,J-K;Huang,Y.;He,W.;Yan,Z-W;Fan,L.;Liu,M-H;Xiao,W-L;Sun,H-D;Chen,G-Q.Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells,CELL DEATH & DISEASE,2014,5():e1400
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