Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells
Hou, J-K1,2; Huang, Y.3; He, W.3; Yan, Z-W3; Fan, L.3; Liu, M-H3; Xiao, W-L4; Sun, H-D4; Chen, G-Q1,2,3,5; Chen,GQ (reprint author),Shandong Jiaotong Univ,Sch Med,Dept Pathophysiol,280 Chong Qing South Rd,Shanghai 200025,Peoples R China.; huangying@shsmu.edu.cn; hdsun@mail.kib.ac.cn; chengq@shsmu.edu.cn
2014-09-01
发表期刊CELL DEATH & DISEASE
ISSN2041-4889
卷号5页码:e1400
产权排序第四
摘要Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs for the prevention and treatment of solid tumors. Therefore, it is of significance to explore the potential activities of adenanthin on solid tumor cells. Here, we demonstrate that Prx I protein is essential for the survival of hepatocellular carcinoma (HCC) cells, and adenanthin can kill these malignant liver cells in vitro and xenografts. We also show that the cell death-inducing activity of adenanthin on HCC cells is mediated by the increased reactive oxygen species (ROS) levels. Furthermore, the silencing of Prx I or Prx II significantly enhances the cytotoxic activity of adenanthin on HCC, whereas the ectopic expression of Prx I and Prx II but not their mutants of adenanthin-bound cysteines can rescue adenanthin-induced cytotoxicity in Prxs-silenced HCC cells. Taken together, our results propose that adenanthin targets Prx I/II to kill HCC cells and its therapeutic significance warrants to be further explored in HCC patients.
关键词Reactive Oxygen Cancer-cells Signaling Pathway Mechanisms Apoptosis Ros Roles Death Prdx1
资助信息National Natural Science Foundation of China [91213304, 81372191, 81230048]; Shanghai Science and Technology Committee [11JC1406800]; Shanghai Committee of Education
学科领域Cell Biology
DOI10.1038/cddis.2014.345
收录类别SCI
语种英语
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000343162000001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18399
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Chen,GQ (reprint author),Shandong Jiaotong Univ,Sch Med,Dept Pathophysiol,280 Chong Qing South Rd,Shanghai 200025,Peoples R China.; huangying@shsmu.edu.cn; hdsun@mail.kib.ac.cn; chengq@shsmu.edu.cn
作者单位1.Chinese Acad Sci, Univ Chinese Acad Sci, SIBS, Inst Hlth Sci, Shanghai, Peoples R China
2.Shandong Jiaotong Univ, Sch Med, Shanghai 200025, Peoples R China
3.Shandong Jiaotong Univ, Sch Med, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis,Chinese Min, Shanghai 200025, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
5.SJTU SM, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China
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GB/T 7714
Hou, J-K,Huang, Y.,He, W.,et al. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells[J]. CELL DEATH & DISEASE,2014,5:e1400.
APA Hou, J-K.,Huang, Y..,He, W..,Yan, Z-W.,Fan, L..,...&chengq@shsmu.edu.cn.(2014).Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.CELL DEATH & DISEASE,5,e1400.
MLA Hou, J-K,et al."Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells".CELL DEATH & DISEASE 5(2014):e1400.
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