Pu,JX (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.
Twenty nine 6,7-seco-ent-kaurane-type diterpenoids including 18 new ones, laxiflorolides C-T (1-18), along with 21 known ones were obtained from Isodon eriocalyx var. laxiflora. Laxiflorolides E-G (3-5) are the first identified naturally occurring 6,7-seco-ent-kauranoids that feature a 3,6-epoxy unit, and laxi-florolide M (11) is the first identified naturally occurring 6-nor-6,7-seco-ent-kauranoid. The absolute configurations of compounds 1, 3, 6, and 11 were determined by single-crystal X-ray diffraction analyses. The cytotoxic activity of the isolates was evaluated by an MTF assay. (C) 2014 Elsevier Ltd. All rights reserved.
1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Wang,Wei-Guang;Yan,Bing-Chao;Li,Xiao-Nian;Du,Xue;Wu,Hai-Yan;Zhan,Rui;Li,Yan;Pu,Jian-Xin;Sun,Han-Dong.6,7-Seco-ent-kaurane-type diterpenoids from Isodon eriocalyx var. laxiflora,TETRAHEDRON,2014,70(41):7445-7453