Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides

doi:10.1016/j.fitote2014.08.012

	Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides
	Wu, Hai-Yan 1,2; Wang, Wei-Guang 1; Jiang, Hua-Yi 1,2; Du, Xue 1; Li, Xiao-Nian 1; Pu, Jian-Xin1 ; Sun, Han-Dong1
	2014-10-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	98 页码:192-198
摘要	Seven new ent-kaurane diterpenoids, isowikstroemins A-G (1-7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1-4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 mu M. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. (C) 2014 Elsevier B.V. All rights reserved.
关键词	Lamiaceae Isodon Wikstroemioides Ent-kaurane Diterpenoid Cytotoxicity
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote2014.08.012
收录类别	SCI
WOS记录号	WOS:000343617600028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18382
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Hai-Yan,Wang, Wei-Guang,Jiang, Hua-Yi,et al. Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides[J]. FITOTERAPIA,2014,98:192-198.
APA	Wu, Hai-Yan.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2014).Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides.FITOTERAPIA,98,192-198.
MLA	Wu, Hai-Yan,et al."Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides".FITOTERAPIA 98(2014):192-198.

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