Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides
Wu, Hai-Yan1,2; Wang, Wei-Guang1; Jiang, Hua-Yi1,2; Du, Xue1; Li, Xiao-Nian1; Pu, Jian-Xin1; Sun, Han-Dong1; Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; pujianxin@mail.kib.ac.cn; hdsun@mail.kib.ac.cn
2014-10-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号98页码:192-198
摘要Seven new ent-kaurane diterpenoids, isowikstroemins A-G (1-7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1-4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 mu M. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. (C) 2014 Elsevier B.V. All rights reserved.
关键词Lamiaceae Isodon Wikstroemioides Ent-kaurane Diterpenoid Cytotoxicity
资助信息National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Yunnan Province [2011C1043]; Major Direction Projection Foundation of CAS Intellectual Innovation Projec [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18382
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; pujianxin@mail.kib.ac.cn; hdsun@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Wu, Hai-Yan,Wang, Wei-Guang,Jiang, Hua-Yi,et al. Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides[J]. FITOTERAPIA,2014,98:192-198.
APA Wu, Hai-Yan.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,Li, Xiao-Nian.,...&hdsun@mail.kib.ac.cn.(2014).Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides.FITOTERAPIA,98,192-198.
MLA Wu, Hai-Yan,et al."Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides".FITOTERAPIA 98(2014):192-198.
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