Hu,QF (reprint author),China Tobacco Yunnan Ind Co Ltd,Key Lab Tobacco Chem Yunnan Prov,Kunming 650231,Peoples R China.
Aspergillines A-E (1-5) are highly oxygenated cyclopiazonic acid (CPA)-derived alkaloids bearing a rigid and sterically congested hexacyclic indole-tetrahydrofuran-tetramate scaffold, isolated from the endophytic fungus Aspergillus vesicolor. Apergillines A-C represent a new subclass of CPA-derived alkaloids, and aspergillines B and E possess a butanoic acid methyl ester moiety. The structures, including absolute configuration, were elucidated by interpretation of the NMR, X-ray crystallographic, and circular dichroism data. All compounds displayed anti-TMV and cytotoxic activities.
1.China Tobacco Yunnan Ind Co Ltd, Key Lab Tobacco Chem Yunnan Prov, Kunming 650231, Peoples R China 2.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China 3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA 6.Univ Illinois, WHO Collaborating Ctr Tradit Med, Coll Pharm, Chicago, IL 60612 USA