| Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production | |
Qin, Zhi-Bin1,2,3; Zhang, Jing1,4; Wu, Xing-De1; He, Juan1; Ding, Lin-Fen2,3; Peng, Li-Yan1; Li, Xing-Yao1; Li, Yan1 ; Deng, Liang2,3; Guo, Ya-Dong2,3; Zhao, Qin-Shi1; Schoch, CL (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.; schoch2@ncbi.nlm.nih.gov
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| 2014-06-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 80期号:8-9页码:703-709 |
| 摘要 | Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 mu M. |
| 关键词 | Tussilago Farfara Asteraceae Sesquiterpenoid Nitric Oxide Inhibition |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-0034-1368567 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338039800015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18278 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Schoch, CL (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.; schoch2@ncbi.nlm.nih.gov |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Zhi-Bin,Zhang, Jing,Wu, Xing-De,et al. Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production[J]. PLANTA MEDICA,2014,80(8-9):703-709. |
| APA | Qin, Zhi-Bin.,Zhang, Jing.,Wu, Xing-De.,He, Juan.,Ding, Lin-Fen.,...&schoch2@ncbi.nlm.nih.gov.(2014).Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production.PLANTA MEDICA,80(8-9),703-709. |
| MLA | Qin, Zhi-Bin,et al."Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production".PLANTA MEDICA 80.8-9(2014):703-709. |
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