Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production
Qin, Zhi-Bin1,2,3; Zhang, Jing1,4; Wu, Xing-De1; He, Juan1; Ding, Lin-Fen2,3; Peng, Li-Yan1; Li, Xing-Yao1; Li, Yan1; Deng, Liang2,3; Guo, Ya-Dong2,3; Zhao, Qin-Shi1; Schoch, CL (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.; schoch2@ncbi.nlm.nih.gov
2014-06-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号80期号:8-9页码:703-709
摘要Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 mu M.
关键词Tussilago Farfara Asteraceae Sesquiterpenoid Nitric Oxide Inhibition
资助信息National Natural Science Foundation of China [U09326024, 081300]; National Basic Research Program of China (973 Program) [2011CB915503, 2009CB522303]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18278
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Schoch, CL (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA.; schoch2@ncbi.nlm.nih.gov
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
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Qin, Zhi-Bin,Zhang, Jing,Wu, Xing-De,et al. Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production[J]. PLANTA MEDICA,2014,80(8-9):703-709.
APA Qin, Zhi-Bin.,Zhang, Jing.,Wu, Xing-De.,He, Juan.,Ding, Lin-Fen.,...&schoch2@ncbi.nlm.nih.gov.(2014).Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production.PLANTA MEDICA,80(8-9),703-709.
MLA Qin, Zhi-Bin,et al."Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production".PLANTA MEDICA 80.8-9(2014):703-709.
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