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题名: Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production
作者: Qin, Zhi-Bin1, 2, 3; Zhang, Jing1, 4; Wu, Xing-De1; He, Juan1; Ding, Lin-Fen2, 3; Peng, Li-Yan1; Li, Xing-Yao1; null(李艳)1; Deng, Liang2, 3; Guo, Ya-Dong2, 3; Zhao, Qin-Shi1
刊名: PLANTA MEDICA
出版日期: 2014-06-01
卷号: 80, 期号:8-9, 页码:703-709
关键词: Tussilago farfara ; Asteraceae ; sesquiterpenoid ; nitric oxide inhibition
学科分类: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI: 10.1055/s-0034-1368567
通讯作者: Schoch, CL (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. ; schoch2@ncbi.nlm.nih.gov
文章类型: Article
英文摘要: Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 mu M.
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: FLOWER BUDS ; CELLS ; L.
收录类别: SCI
语种: 英语
WOS记录号: WOS:000338039800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18278
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China

Recommended Citation:
Qin,Zhi-Bin;Zhang,Jing;Wu,Xing-De;He,Juan;Ding,Lin-Fen;Peng,Li-Yan;Li,Xing-Yao;Li,Yan;Deng,Liang;Guo,Ya-Dong;Zhao,Qin-Shi.Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production,PLANTA MEDICA,2014,80(8-9):703-709
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