The anticancer effect and mechanism of alpha-hederin on breast cancer cells
Cheng, Lin1; Xia, Tian-Song1; Wang, Yi-Fen3; Zhou, Wenbin1; Liang, Xiu-Qing1; Xue, Jin-Qiu1; Shi, Liang1; Wang, Ying1; Ding, Qiang1; Wang, Minhai2; Ding, Q (reprint author), Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Breast Dis Ctr, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
2014-08-01
发表期刊INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN1019-6439
卷号45期号:2页码:757-763
产权排序第三
摘要Natural plant products occupy a very important position in the area of cancer chemotherapy. Many triterpenoid saponins have been proved as potential agents for chemoprevention and therapy of breast cancer. alpha-hederin, a monodesmosidic triterpenoid saponin distributed in Hedera or Nigel la species, displays many biological activities. It is increasingly investigated for its promising anticancer potential since it has been shown to have cytotoxicity against several types of cancer cells. However, studies of alpha-hederin on breast cancer are limited, most of which focus on biological activity, while the mechanisms have not been widely reported yet. Previously, we purified and identified alpha-hederin from Clematis ganpiniana, a herb used in traditional Chinese medicine with antitumor action. In the present study, alpha-hederin showed strong inhibitory activity on the growth of breast cancer cells and induced apoptosis in these cells. alpha-hederin induced depolarization of mitochondrial membrane potential which released Apaf-1 and cytochrome c from the intermembrane space into the cytosol, where they promoted caspase-3 and caspase-9 activation. This is the first report on the growth inhibition and pro-apoptotic effects of alpha-hederin on breast cancer cells and the relative apoptosis pathways. It implied that triterpenoid saponin alpha-hederin could be a promising candidate for chemotherapy of breast cancer.
关键词Alpha-hederin Breast Cancer Apoptosis Mechanism Mitochondria
资助信息Natural Science Foundation of China [81272916, 81202077, 81372828]; Natural Science Foundation of Jiangsu Province [BK2011855]; Jiangsu Provincial Health Office [H201110]; Jiangsu Province Traditional Chinese Medicine Bureau [LZ11084]; Six Talents Peak projects of Jiangsu Province; Priority Academic Program Development of Jiangsu higher Education Institutions (PAPD); Talent Foundation of The First Affiliated Yijishan Hospital of Wannan Medical College [YR201305]
学科领域Oncology
DOI10.3892/ijo.2014.2449
收录类别SCI
语种英语
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000338484600033
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18275
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Ding, Q (reprint author), Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Breast Dis Ctr, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
作者单位1.Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Breast Dis Ctr, Nanjing 210029, Jiangsu, Peoples R China
2.Wannan Med Coll, Affiliated Yijishan Hosp 1, Dept Gen Surg, Wuhu 241001, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Cheng, Lin,Xia, Tian-Song,Wang, Yi-Fen,et al. The anticancer effect and mechanism of alpha-hederin on breast cancer cells[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2014,45(2):757-763.
APA Cheng, Lin.,Xia, Tian-Song.,Wang, Yi-Fen.,Zhou, Wenbin.,Liang, Xiu-Qing.,...&Ding, Q .(2014).The anticancer effect and mechanism of alpha-hederin on breast cancer cells.INTERNATIONAL JOURNAL OF ONCOLOGY,45(2),757-763.
MLA Cheng, Lin,et al."The anticancer effect and mechanism of alpha-hederin on breast cancer cells".INTERNATIONAL JOURNAL OF ONCOLOGY 45.2(2014):757-763.
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