Ding, Q (reprint author), Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Breast Dis Ctr, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
Natural plant products occupy a very important position in the area of cancer chemotherapy. Many triterpenoid saponins have been proved as potential agents for chemoprevention and therapy of breast cancer. alpha-hederin, a monodesmosidic triterpenoid saponin distributed in Hedera or Nigel la species, displays many biological activities. It is increasingly investigated for its promising anticancer potential since it has been shown to have cytotoxicity against several types of cancer cells. However, studies of alpha-hederin on breast cancer are limited, most of which focus on biological activity, while the mechanisms have not been widely reported yet. Previously, we purified and identified alpha-hederin from Clematis ganpiniana, a herb used in traditional Chinese medicine with antitumor action. In the present study, alpha-hederin showed strong inhibitory activity on the growth of breast cancer cells and induced apoptosis in these cells. alpha-hederin induced depolarization of mitochondrial membrane potential which released Apaf-1 and cytochrome c from the intermembrane space into the cytosol, where they promoted caspase-3 and caspase-9 activation. This is the first report on the growth inhibition and pro-apoptotic effects of alpha-hederin on breast cancer cells and the relative apoptosis pathways. It implied that triterpenoid saponin alpha-hederin could be a promising candidate for chemotherapy of breast cancer.
1.Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Breast Dis Ctr, Nanjing 210029, Jiangsu, Peoples R China 2.Wannan Med Coll, Affiliated Yijishan Hosp 1, Dept Gen Surg, Wuhu 241001, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Cheng, Lin,Xia, Tian-Song,Wang, Yi-Fen,et al. The anticancer effect and mechanism of alpha-hederin on breast cancer cells[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2014,45(2):757-763.