Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia
Zeng, Junfen1; Xue, Yongbo1; Shu, Penghua1; Qian, Huiqin1; Sa, Rongjian2; Xiang, Ming1; Li, Xiao-Nian3; Luo, Zengwei1; Yao, Guangmin1; Zhang, Yonghui1; Yao, GM (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China.; gyap@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn
2014-08-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume77Issue:8Pages:1948-1954
Contribution Rank第三
AbstractThree new diterpenoids with unprecedented carbon skeletons, cinncassiols F (1) and G (2) and 16-O-beta-D-glucopyranosyl-19-deoxycinncassiol G (3), a new isoryanodane diterpenoid, 18-hydroxyperseanol (4), six known isoryanodane diterpenoids, 5-10, and a known ryanodane diterpenoid, 11, were isolated from the stem bark of Cinnamomum cassia. Compound 1 possesses an 11,13:12,13-diepoxy-6,11-epoxy:12,13-disecoisoryanodane diterpenoid skeleton bearing ketal and hemiketal functionalities, whereas compounds 2 and 3 feature an 11,12-secoisoryanodane diterpenoid skeleton with an 11,6-lactone moiety. The structures of the four new diterpenoids, 1-4, and their absolute configurations were established using HRESIMS, NMR, ECD, single-crystal X-ray diffraction, and chemical methods. Compounds 2 and 11 significantly inhibited the proliferation of murine T cells induced by ConA.
KeywordAbsolute-configuration Constituents Cortex Glucoside
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np500465g
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000340861800025
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18274
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorYao, GM (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China.; gyap@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China
2.Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian Province, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan Province, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Junfen,Xue, Yongbo,Shu, Penghua,et al. Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1948-1954.
APA Zeng, Junfen.,Xue, Yongbo.,Shu, Penghua.,Qian, Huiqin.,Sa, Rongjian.,...&zhangyh@mails.tjmu.edu.cn.(2014).Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia.JOURNAL OF NATURAL PRODUCTS,77(8),1948-1954.
MLA Zeng, Junfen,et al."Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1948-1954.
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