| Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia | |
| Zeng, Junfen1; Xue, Yongbo1; Shu, Penghua1; Qian, Huiqin1; Sa, Rongjian2; Xiang, Ming1; Li, Xiao-Nian3; Luo, Zengwei1; Yao, Guangmin1; Zhang, Yonghui1; Yao, GM (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China.; gyap@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn | |
| 2014-08-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| 卷号 | 77期号:8页码:1948-1954 |
| 摘要 | Three new diterpenoids with unprecedented carbon skeletons, cinncassiols F (1) and G (2) and 16-O-beta-D-glucopyranosyl-19-deoxycinncassiol G (3), a new isoryanodane diterpenoid, 18-hydroxyperseanol (4), six known isoryanodane diterpenoids, 5-10, and a known ryanodane diterpenoid, 11, were isolated from the stem bark of Cinnamomum cassia. Compound 1 possesses an 11,13:12,13-diepoxy-6,11-epoxy:12,13-disecoisoryanodane diterpenoid skeleton bearing ketal and hemiketal functionalities, whereas compounds 2 and 3 feature an 11,12-secoisoryanodane diterpenoid skeleton with an 11,6-lactone moiety. The structures of the four new diterpenoids, 1-4, and their absolute configurations were established using HRESIMS, NMR, ECD, single-crystal X-ray diffraction, and chemical methods. Compounds 2 and 11 significantly inhibited the proliferation of murine T cells induced by ConA. |
| 关键词 | Absolute-configuration Constituents Cortex Glucoside |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np500465g |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000340861800025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18274 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Yao, GM (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China.; gyap@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China 2.Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian Province, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Junfen,Xue, Yongbo,Shu, Penghua,et al. Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1948-1954. |
| APA | Zeng, Junfen.,Xue, Yongbo.,Shu, Penghua.,Qian, Huiqin.,Sa, Rongjian.,...&zhangyh@mails.tjmu.edu.cn.(2014).Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia.JOURNAL OF NATURAL PRODUCTS,77(8),1948-1954. |
| MLA | Zeng, Junfen,et al."Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1948-1954. |
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