Nine oxygenated guaiane-type sesquiterpenes and three isopimarane diterpenes were isolated from the culture broth of an endophytic fungus. Xylaria sp. YM 311647, obtained from Azadirachta indica. The structures of these compounds were elucidated by interpretation of spectroscopic data. The absolute configurations of two of these were confirmed by X-ray crystallographic analysis. All of the compounds were tested for their antifungal activities against five pathogenic fungal cells. The results showed that nine sesquiterpenes were moderately active against Candida albicans and Hormodendrum compactum with MIC values ranging from 32 to 256 mu g/ml, while the diterpenes were more active; One of these exhibited the most potent inhibitory activity against C albicans and Pyricularia olyzae with MIC values of 16 mu g/ml. (C) 2014 Elsevier Ltd. All rights reserved.
1.Yunnan Univ, Yunnan Inst Microbiol, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Peoples R China 2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
Wu,Shao-Hua;He,Jian;Li,Xiao-Nian;Huang,Rong;Song,Fei;Chen,You-Wei;Miao,Cui-Ping.Guaiane sesquiterpenes and isopimarane diterpenes from an endophytic fungus Xylaria sp.,PHYTOCHEMISTRY,2014,105():197-204