Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr
Huang, Sheng-Zhuo1,2; Zhang, Xuan3; Ma, Qing-Yun1; Peng, Hua2; Zheng, Yong-Tang3; Hu, Jiang-Miao2; Dai, Hao-Fu1; Zhou, Jun2; Zhao, You-Xing1; Zhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; junzhou3264@126.com; zhaoyx1011@163.com
2014-06-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号95页码:34-41
摘要Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerzfolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 mu M, SI >1,836.9,431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates. (C) 2014 Elsevier B.V. All rights reserved.
关键词Excoecaria Acerifolia Euphorbiaceae Excoecafolin Anti-hiv-1 Chemotaxonomy
资助信息National Natural Science Foundation of China [31300294];Special Fund for Agro-scientific Research in the Public Interest [201303117];National Support Science and Technology Subject [2013BAI11804];Major Technology Project of Hainan [ZDZX2013008-4, ZDZX2013023-1]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2014.02.018
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000336819400005
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18187
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; junzhou3264@126.com; zhaoyx1011@163.com
作者单位1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650204, Peoples R China
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Huang, Sheng-Zhuo,Zhang, Xuan,Ma, Qing-Yun,et al. Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr[J]. FITOTERAPIA,2014,95:34-41.
APA Huang, Sheng-Zhuo.,Zhang, Xuan.,Ma, Qing-Yun.,Peng, Hua.,Zheng, Yong-Tang.,...&zhaoyx1011@163.com.(2014).Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr.FITOTERAPIA,95,34-41.
MLA Huang, Sheng-Zhuo,et al."Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr".FITOTERAPIA 95(2014):34-41.
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