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Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis
Yu, Yang1,2,3; Hayashi, Shuhei2,4; Cai, Xianbin2; Fang, Chongye2,5; Shi, Wei1; Tsutsui, Hiroko2,4; Sheng, Jun5; Hayashi,SH (reprint author),Hyogo Coll Med,Dept Pu Erh Tea & Med Sci,1-1 Mukogawa Cho,Nishinomiya,Hyogo 6638501,Japan.; zoup1130@hyo-med.ac.jp; shengj@ynau.edu.cn
2014
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
Pages254680
AbstractFET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATAbinding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. There is currently no cure for this disease and few effective treatments are available. Epidemiological studies indicate that the consumption of tea is associated with a reduced risk of developing neurodegenerative diseases. The results of this study revealed that components of a pu-erh tea extract (PTE) interacted with FET family proteins but not with TDP-43 or SOD1. PTE induced the degradation of FET family proteins but had no effects on TDP-43 or SOD1. The most frequently occurring ALS-linked FUS/TLS mutant protein, R521C FUS/TLS, was also degraded in the presence of PTE. Furthermore, ammonium chloride, a lysosome inhibitor, but not lactacystin, a proteasome inhibitor, reduced the degradation of FUS/TLS protein by PTE. PTE significantly reduced the incorporation of R521C FUS/TLS into stress granules under stress conditions. These findings suggest that PTE may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.
KeywordWild-type Fus Stress Granules Alpha-synuclein Amyloid-beta Mutations Tdp-43 Toxicity Fibrils Gene Fermentation
Subject AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
DOI10.1155/2014/254680
Indexed BySCI
Language英语
WOS IDWOS:000334767700001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18160
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorHayashi,SH (reprint author),Hyogo Coll Med,Dept Pu Erh Tea & Med Sci,1-1 Mukogawa Cho,Nishinomiya,Hyogo 6638501,Japan.; zoup1130@hyo-med.ac.jp; shengj@ynau.edu.cn
Affiliation1.Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130012, Peoples R China
2.Hyogo Coll Med, Dept Pu Erh Tea & Med Sci, Nishinomiya, Hyogo 6638501, Japan
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Hyogo Coll Med, Dept Microbiol, Nishinomiya, Hyogo 6638501, Japan
5.Yunnan Agr Univ, Minist Educ, Key Lab Pu Erh Tea Sci, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Yu, Yang,Hayashi, Shuhei,Cai, Xianbin,et al. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis[J]. BIOMED RESEARCH INTERNATIONAL,2014:254680.
APA Yu, Yang.,Hayashi, Shuhei.,Cai, Xianbin.,Fang, Chongye.,Shi, Wei.,...&shengj@ynau.edu.cn.(2014).Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis.BIOMED RESEARCH INTERNATIONAL,254680.
MLA Yu, Yang,et al."Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis".BIOMED RESEARCH INTERNATIONAL (2014):254680.
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