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题名: Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis
作者: Yu, Yang1, 2, 3; Hayashi, Shuhei2, 4; Cai, Xianbin2; Fang, Chongye2, 5; Shi, Wei1; Tsutsui, Hiroko2, 4; Sheng, Jun5
刊名: BIOMED RESEARCH INTERNATIONAL
关键词: WILD-TYPE FUS ; STRESS GRANULES ; ALPHA-SYNUCLEIN ; AMYLOID-BETA ; MUTATIONS ; TDP-43 ; TOXICITY ; FIBRILS ; GENE ; FERMENTATION
英文摘要: FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATAbinding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. There is currently no cure for this disease and few effective treatments are available. Epidemiological studies indicate that the consumption of tea is associated with a reduced risk of developing neurodegenerative diseases. The results of this study revealed that components of a pu-erh tea extract (PTE) interacted with FET family proteins but not with TDP-43 or SOD1. PTE induced the degradation of FET family proteins but had no effects on TDP-43 or SOD1. The most frequently occurring ALS-linked FUS/TLS mutant protein, R521C FUS/TLS, was also degraded in the presence of PTE. Furthermore, ammonium chloride, a lysosome inhibitor, but not lactacystin, a proteasome inhibitor, reduced the degradation of FUS/TLS protein by PTE. PTE significantly reduced the incorporation of R521C FUS/TLS into stress granules under stress conditions. These findings suggest that PTE may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.
出版日期: 2014
页码: 254680
语种: 英语
收录类别: SCI
学科分类: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
ISSN号: 2314-6133
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18160
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130012, Peoples R China
2.Hyogo Coll Med, Dept Pu Erh Tea & Med Sci, Nishinomiya, Hyogo 6638501, Japan
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Hyogo Coll Med, Dept Microbiol, Nishinomiya, Hyogo 6638501, Japan
5.Yunnan Agr Univ, Minist Educ, Key Lab Pu Erh Tea Sci, Kunming 650201, Peoples R China

Recommended Citation:
Yu,Yang;Hayashi,Shuhei;Cai,Xianbin;Fang,Chongye;Shi,Wei;Tsutsui,Hiroko;Sheng,Jun.Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis,BIOMED RESEARCH INTERNATIONAL,2014,():254680
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