The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells
Ge, Hu1,2; Liu, Ge3; Xiang, Yang-Fei4,5; Wang, Yu1,2; Guo, Chao-Wan3; Chen, Nan-Hao1,2; Zhang, Ying-Jun6; Wang, Yi-Fei4; Kitazato, Kaio3; Xu, Jun1,2
Corresponding AuthorWang,YF (reprint author),Jinan Univ,Natl Engn Res Ctr Genet Med,Guangdong Prov Key Lab Bioengn Med,Div Biomed,Res & Dev Ctr,Guangzhou,Guangdong,Peoples R China. ; twang-yf@163.com ; kkholi@nagasaki-u.ac.jp ; junxu@biochemomes.com
2014-04-09
Source PublicationPLOS ONE
ISSN1932-6203
Volume9Issue:4Pages:e94392
AbstractHemagglutinin (HA) is essential for Influenza A virus infection, but its diversity of subtypes presents an obstacle to developing broad-spectrum HA inhibitors. In this study, we investigated the molecular mechanisms by which poly-galloyl glucose (pGG) analogs inhibit influenza hemagglutinin (HA) in vitro and in silico. We found that (1) star-shaped pGG analogs exhibit HA-inhibition activity by interacting with the conserved structural elements of the receptor binding domain (RBD); (2) HA inhibition depends on the number of galloyl substituents in a pGG analog; the best number is four; and when PGG binds with two HA trimers at their conserved receptor binding domains (loop 130, loop 220, and 190-alpha-helix), PGG acts as a molecular glue by aggregating viral particles so as to prevent viral entry into host cells (this was revealed via an in silico simulation on the binding of penta- galloyl-glucose (PGG) with HA). pGGs are also effective on a broad-spectrum influenza A subtypes (including H1, H3, H5, H7); this suggests that pGG analogs can be applied to most influenza A subtypes as a prophylactic against influenza viral infections.
KeywordReceptor-binding Properties Molecular-dynamics Human Infection Hemagglutinin Transmission Fusion Origin Amber
Subject AreaScience & Technology - Other Topics
DOI10.1371/journal.pone.0094392
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000334339000114
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18128
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Inst Human Virol, Guangzhou 510275, Guangdong, Peoples R China
3.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 852, Japan
4.Jinan Univ, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Div Biomed,Res & Dev Ctr, Guangzhou, Guangdong, Peoples R China
5.Jinan Univ, Coll Pharm, Guangzhou, Guangdong, Peoples R China
6.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Ge, Hu,Liu, Ge,Xiang, Yang-Fei,et al. The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells[J]. PLOS ONE,2014,9(4):e94392.
APA Ge, Hu.,Liu, Ge.,Xiang, Yang-Fei.,Wang, Yu.,Guo, Chao-Wan.,...&Xu, Jun.(2014).The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells.PLOS ONE,9(4),e94392.
MLA Ge, Hu,et al."The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells".PLOS ONE 9.4(2014):e94392.
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