中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells
作者: Ge, Hu1, 2; Liu, Ge3; Xiang, Yang-Fei4, 5; Wang, Yu1, 2; Guo, Chao-Wan3; Chen, Nan-Hao1, 2; null(张颖君)6; Wang, Yi-Fei4; Kitazato, Kaio3; Xu, Jun1, 2
刊名: PLOS ONE
关键词: RECEPTOR-BINDING PROPERTIES ; MOLECULAR-DYNAMICS ; HUMAN INFECTION ; HEMAGGLUTININ ; TRANSMISSION ; FUSION ; ORIGIN ; AMBER
英文摘要: Hemagglutinin (HA) is essential for Influenza A virus infection, but its diversity of subtypes presents an obstacle to developing broad-spectrum HA inhibitors. In this study, we investigated the molecular mechanisms by which poly-galloyl glucose (pGG) analogs inhibit influenza hemagglutinin (HA) in vitro and in silico. We found that (1) star-shaped pGG analogs exhibit HA-inhibition activity by interacting with the conserved structural elements of the receptor binding domain (RBD); (2) HA inhibition depends on the number of galloyl substituents in a pGG analog; the best number is four; and when PGG binds with two HA trimers at their conserved receptor binding domains (loop 130, loop 220, and 190-alpha-helix), PGG acts as a molecular glue by aggregating viral particles so as to prevent viral entry into host cells (this was revealed via an in silico simulation on the binding of penta- galloyl-glucose (PGG) with HA). pGGs are also effective on a broad-spectrum influenza A subtypes (including H1, H3, H5, H7); this suggests that pGG analogs can be applied to most influenza A subtypes as a prophylactic against influenza viral infections.
出版日期: 2014-04-09
卷号: 9, 期号:4, 页码:e94392
语种: 英语
收录类别: SCI
学科分类: Science & Technology - Other Topics
ISSN号: 1932-6203
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18128
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Ge-2014-The Mechanism of Pol.pdf(4149KB)----开放获取View Download

作者单位: 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Inst Human Virol, Guangzhou 510275, Guangdong, Peoples R China
3.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 852, Japan
4.Jinan Univ, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Div Biomed,Res & Dev Ctr, Guangzhou, Guangdong, Peoples R China
5.Jinan Univ, Coll Pharm, Guangzhou, Guangdong, Peoples R China
6.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China

Recommended Citation:
Ge,Hu;Liu,Ge;Xiang,Yang-Fei;Wang,Yu;Guo,Chao-Wan;Chen,Nan-Hao;Zhang,Ying-Jun;Wang,Yi-Fei;Kitazato,Kaio;Xu,Jun.The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells,PLOS ONE,2014,9(4):e94392
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ge, Hu]'s Articles
[Liu, Ge]'s Articles
[Xiang, Yang-Fei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ge, Hu]‘s Articles
[Liu, Ge]‘s Articles
[Xiang, Yang-Fei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Ge-2014-The Mechanism of Pol.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace