The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells
Ge, Hu1,2; Liu, Ge3; Xiang, Yang-Fei4,5; Wang, Yu1,2; Guo, Chao-Wan3; Chen, Nan-Hao1,2; Zhang, Ying-Jun6; Wang, Yi-Fei4; Kitazato, Kaio3; Xu, Jun1,2
2014-04-09
发表期刊PLOS ONE
ISSN1932-6203
卷号9期号:4页码:e94392
摘要Hemagglutinin (HA) is essential for Influenza A virus infection, but its diversity of subtypes presents an obstacle to developing broad-spectrum HA inhibitors. In this study, we investigated the molecular mechanisms by which poly-galloyl glucose (pGG) analogs inhibit influenza hemagglutinin (HA) in vitro and in silico. We found that (1) star-shaped pGG analogs exhibit HA-inhibition activity by interacting with the conserved structural elements of the receptor binding domain (RBD); (2) HA inhibition depends on the number of galloyl substituents in a pGG analog; the best number is four; and when PGG binds with two HA trimers at their conserved receptor binding domains (loop 130, loop 220, and 190-alpha-helix), PGG acts as a molecular glue by aggregating viral particles so as to prevent viral entry into host cells (this was revealed via an in silico simulation on the binding of penta- galloyl-glucose (PGG) with HA). pGGs are also effective on a broad-spectrum influenza A subtypes (including H1, H3, H5, H7); this suggests that pGG analogs can be applied to most influenza A subtypes as a prophylactic against influenza viral infections.
关键词Receptor-binding Properties Molecular-dynamics Human Infection Hemagglutinin Transmission Fusion Origin Amber
资助信息National High Technology Research and Development Program of China (863 Program) [2012AA020307]; Guangdong Recruitment Program of Creative Research Groups; National Natural Science Foundation of China [81173470, 81274170]; Special Funding Program for the National Supercomputer Center in Guangzhou [2012Y2-00048/2013Y2-00045, 201200000037]; Tokyo Biochemical Research Foundation; Ministry of Education, Culture, Sports, Science and Technology of Japan [22590274]
学科领域Science & Technology - Other Topics
DOI10.1371/journal.pone.0094392
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000334339000114
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18128
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Inst Human Virol, Guangzhou 510275, Guangdong, Peoples R China
3.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 852, Japan
4.Jinan Univ, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Div Biomed,Res & Dev Ctr, Guangzhou, Guangdong, Peoples R China
5.Jinan Univ, Coll Pharm, Guangzhou, Guangdong, Peoples R China
6.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
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GB/T 7714
Ge, Hu,Liu, Ge,Xiang, Yang-Fei,et al. The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells[J]. PLOS ONE,2014,9(4):e94392.
APA Ge, Hu.,Liu, Ge.,Xiang, Yang-Fei.,Wang, Yu.,Guo, Chao-Wan.,...&Xu, Jun.(2014).The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells.PLOS ONE,9(4),e94392.
MLA Ge, Hu,et al."The Mechanism of Poly-Galloyl-Glucoses Preventing Influenza A Virus Entry into Host Cells".PLOS ONE 9.4(2014):e94392.
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