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题名: Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
作者: Wu, Hai-Yan1, 2; Zhan, Rui1; Wang, Wei-Guang1; Jiang, Hua-Yi1, 2; Du, Xue1; Li, Xiao-Nian1; null(李艳)1; Pu, Jian-Xin1; null(孙汉董)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: RUBESCENS VAR.-TAIHANGENSIS ; KAURENE DITERPENOIDS ; MAOECRYSTAL-V ; C-H ; ERIOCALYX ; SKELETON
英文摘要: Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
出版日期: 2014-04-01
卷号: 77, 期号:4, 页码:931-941
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences ; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18122
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Wu,Hai-Yan;Zhan,Rui;Wang,Wei-Guang;Jiang,Hua-Yi;Du,Xue;Li,Xiao-Nian;Li,Yan;Pu,Jian-Xin;Sun,Han-Dong.Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides,JOURNAL OF NATURAL PRODUCTS,2014,77(4):931-941
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