Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides

doi:10.1021/np4010135

	Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
	Wu, Hai-Yan 1,2; Zhan, Rui 1; Wang, Wei-Guang 1; Jiang, Hua-Yi 1,2; Du, Xue 1; Li, Xiao-Nian 1; Li, Yan1 ; Pu, Jian-Xin1 ; Sun, Han-Dong1
	2014-04-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	77 期号:4 页码:931-941
摘要	Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
关键词	Rubescens Var.-taihangensis Kaurene Diterpenoids Maoecrystal-v C-h Eriocalyx Skeleton
资助信息	National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Reservation-Talent Project of Yunnan Province [2011CI043]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
收录类别	SCI ; IC
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18122
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Hai-Yan,Zhan, Rui,Wang, Wei-Guang,et al. Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):931-941.
APA	Wu, Hai-Yan.,Zhan, Rui.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,...&Sun, Han-Dong.(2014).Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides.JOURNAL OF NATURAL PRODUCTS,77(4),931-941.
MLA	Wu, Hai-Yan,et al."Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides".JOURNAL OF NATURAL PRODUCTS 77.4(2014):931-941.

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