Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
Wu, Hai-Yan1,2; Zhan, Rui1; Wang, Wei-Guang1; Jiang, Hua-Yi1,2; Du, Xue1; Li, Xiao-Nian1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1
2014-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号77期号:4页码:931-941
摘要Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
关键词Rubescens Var.-taihangensis Kaurene Diterpenoids Maoecrystal-v C-h Eriocalyx Skeleton
资助信息National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Reservation-Talent Project of Yunnan Province [2011CI043]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np4010135
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000335127200027
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18122
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Wu, Hai-Yan,Zhan, Rui,Wang, Wei-Guang,et al. Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):931-941.
APA Wu, Hai-Yan.,Zhan, Rui.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,...&Sun, Han-Dong.(2014).Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides.JOURNAL OF NATURAL PRODUCTS,77(4),931-941.
MLA Wu, Hai-Yan,et al."Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides".JOURNAL OF NATURAL PRODUCTS 77.4(2014):931-941.
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