Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation:
Wu,Hai-Yan;Zhan,Rui;Wang,Wei-Guang;Jiang,Hua-Yi;Du,Xue;Li,Xiao-Nian;Li,Yan;Pu,Jian-Xin;Sun,Han-Dong.Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides,JOURNAL OF NATURAL PRODUCTS,2014,77(4):931-941
