| Biologically Active Dichapetalins from Dichapetalum gelonioides | |
Jing, Shu-Xi1,3; Luo, Shi-Hong1; Li, Chun-Huan1; Hua, Juan1; Wang, Yan-Li2; Niu, Xue-Mei2; Li, Xiao-Nian1; Liu, Yan1; Huang, Chun-Shuai1; Wang, Ying1; Li, Sheng-Hong1
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| 通讯作者 | Li,SH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; shli@mail.kib.ac.cn |
| 2014-04-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 77期号:4页码:882-893 |
| 摘要 | A phytochemical investigation of the toxic tropical plant Dichapetalum gelonioides led to the isolation and identification of 14 new dichapetalins (1-14) and the known dichapetalins A (15) and K (16). The structures of the new compounds were determined by analyses of their NMR, MS, electronic circular dichroism, and X-ray diffraction data. The esterification at C-25 by 4-hydroxyphenylpropanoic acid and the hydroxylation at C-2' are unique in this unusual class of natural products. In addition to the known cytotoxicity, an array of biological activities, including antifeedant, nematicidal, antifungal, and NO and AChE inhibitory activities, were observed for this class of compounds. These findings suggested that dichapetalin hybrid triterpenoids as a class have broad biologically active cellular functions including defense against insect herbivores and pathogens. |
| 关键词 | Defensive Sesterterpenoids Glandular Trichomes Triterpenoids Constituents Derivatives Harbor |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np400971r |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000335127200021 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18121 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Yunnan Univ, Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Shu-Xi,Luo, Shi-Hong,Li, Chun-Huan,et al. Biologically Active Dichapetalins from Dichapetalum gelonioides[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):882-893. |
| APA | Jing, Shu-Xi.,Luo, Shi-Hong.,Li, Chun-Huan.,Hua, Juan.,Wang, Yan-Li.,...&Li, Sheng-Hong.(2014).Biologically Active Dichapetalins from Dichapetalum gelonioides.JOURNAL OF NATURAL PRODUCTS,77(4),882-893. |
| MLA | Jing, Shu-Xi,et al."Biologically Active Dichapetalins from Dichapetalum gelonioides".JOURNAL OF NATURAL PRODUCTS 77.4(2014):882-893. |
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| Jing-2014-Biological（392KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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