Daphnane-Type Diterpenoid Glucosides and Further Constituents of Euphorbia pilosa
Zhang, Xu-Dong1,2; Ni, Wei1; Yan, Huan1; Li, Gen-Tao1; Zhong, Hui-Min2; Li, Yan1; Liu, Hai-Yang1
2014-05-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号11期号:5页码:760-766
摘要Phytochemical investigation of whole plants of Euphorbia pilosa led to the isolation and identification of two new daphnane-diterpenoid glucosides, euphopilosides A and B (1 and 2, resp.), and a new ent-abietane, euphopilolide (3), together with eight known compounds. Compounds 1 and 2 are the first daphnane-type diterpenoid glycosides. Their structures were elucidated by a combination of 1D- and 2D-NMR, and MS analyses, and acid hydrolysis. Compounds 1-9 were evaluated for their in vitro cytotoxicities against five human tumor cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compound 7 showed moderate inhibitory activity against all five cell lines.
关键词Euphorbia Pilosa Diterpenoids Daphnane Glycosides Cytotoxic Activity
资助信息National Natural Science Funding of China [31170333, 81072543]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2008PY066]; Academy-Locality Cooperation Project of Chinese Academy of Sciences [XBKM-2011-004]; State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ02]
学科领域Biochemistry & Molecular Biology ; Chemistry
DOI10.1002/cbdv.201300154
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000336376200007
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18105
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China
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Zhang, Xu-Dong,Ni, Wei,Yan, Huan,et al. Daphnane-Type Diterpenoid Glucosides and Further Constituents of Euphorbia pilosa[J]. CHEMISTRY & BIODIVERSITY,2014,11(5):760-766.
APA Zhang, Xu-Dong.,Ni, Wei.,Yan, Huan.,Li, Gen-Tao.,Zhong, Hui-Min.,...&Liu, Hai-Yang.(2014).Daphnane-Type Diterpenoid Glucosides and Further Constituents of Euphorbia pilosa.CHEMISTRY & BIODIVERSITY,11(5),760-766.
MLA Zhang, Xu-Dong,et al."Daphnane-Type Diterpenoid Glucosides and Further Constituents of Euphorbia pilosa".CHEMISTRY & BIODIVERSITY 11.5(2014):760-766.
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