Diterpenoids from Isodon sculponeatus
Jiang, Hua-Yi1,2; Wang, Wei-Guang1; Zhou, Min1,2; Wu, Hai-Yan1,2; Zhan, Rui1; Li, Xiao-Nian1; Du, Xue1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1
2014-03-01
发表期刊FITOTERAPIA
卷号93期号:93页码:142-149
摘要Phytochemical investigation of the aerial parts of Isodon sculponeatus afforded six new 7,20-epoxy-ent-kauranoids, sculponins U-Z (1-6), and 11 known diterpenoids (7-17). The structures of these new compounds were elucidated primarily by means of extensive spectroscopic analysis, and the absolute configuration of 1 was determined by single crystal X-ray diffraction. Compound 5 exhibited weak cytotoxic activity against HL-60, SMMC-7721, MCF-7, and SW-480 cell lines, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50, value of 13.8 mu M. (C) 2014 Elsevier B.V. All rights reserved.
关键词Isodon Sculponeatus Diterpenoids X-ray Diffraction Cytotoxicity Anti-inflammatory Activity
DOI10.1016/j.fitote.2013.12.025
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000333494500018
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18056
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Jiang, Hua-Yi,Wang, Wei-Guang,Zhou, Min,et al. Diterpenoids from Isodon sculponeatus[J]. FITOTERAPIA,2014,93(93):142-149.
APA Jiang, Hua-Yi.,Wang, Wei-Guang.,Zhou, Min.,Wu, Hai-Yan.,Zhan, Rui.,...&Sun, Han-Dong.(2014).Diterpenoids from Isodon sculponeatus.FITOTERAPIA,93(93),142-149.
MLA Jiang, Hua-Yi,et al."Diterpenoids from Isodon sculponeatus".FITOTERAPIA 93.93(2014):142-149.
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