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题名: Structural characterization and immunomodulatory effect of a polysaccharide HCP-2 from Houttuynia cordata
作者: Cheng, Bao-Hui1, 2; Chan, Judy Yuet-Wa1, 2; Chan, Ben Chung-Lap1, 2; Lin, Huang-Quan1, 2; Han, Xiao-Qiang1, 2; Zhou, Xuelin1, 2; Wan, David Chi-Cheong3; null(王易芬)4; Leung, Ping-Chung1, 2; Fung, Kwok-Pui1, 2, 3; Bik-San Lau, Clara1, 2
刊名: CARBOHYDRATE POLYMERS
关键词: Houttuynia cordata ; Pectic polysaccharide ; HCP-2 ; Structural characterization ; Immunomodulation
英文摘要: Immunomodulation of natural polysaccharides has been the hot topic of research in recent years. In order to explore the immunomodulatory effect of Houttuynia cordata Thunb., the water extract was studied and a polysaccharide HCP-2 with molecular weight of 60,000 Da was isolated by chromatography using DEAE Sepharose CL-6B and Sephacryl S-400 HR columns. The structure characterization of HCP-2 was performed by Fourier transform infrared spectroscopy (FTIR), acidic hydrolysis, PMP derivation, HPLC analysis and nuclear magnetic resonance spectra (NMR). HCP-2 was elucidated as a pectic polysaccharide with a linear chain of 1,4-linked alpha-D-galacturonic acid residues in which part of the 6-carboxyl groups were methyl esterified and part of 2-hydroxyl groups were acetylated. The bioactivity assays showed that HCP-2 could increase the secretions of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), macrophage inhibitory protein-1 alpha (MIP-1 alpha), macrophage inhibitory protein-1 beta (MIP-1 beta), and RANTES (regulated on activation, normal T cell expressed and secreted) in human peripheral blood mononuclear cells (PBMCs), which play critical roles in the innate immune system and shape the adaptive immunity. Our results implied that HCP-2 could be an immune enhancer. (C) 2013 Elsevier Ltd. All rights reserved.
出版日期: 2014-03-15
卷号: 103, 页码:244-249
语种: 英语
收录类别: SCI
学科分类: Chemistry, Applied ; Chemistry, Organic ; Polymer Science
ISSN号: 0144-8617
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18049
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China
4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China

Recommended Citation:
Cheng,Bao-Hui;Chan,JudyYuet-Wa;Chan,BenChung-Lap;Lin,Huang-Quan;Han,Xiao-Qiang;Zhou,Xuelin;Wan,DavidChi-Cheong;Wang,Yi-Fen;Leung,Ping-Chung;Fung,Kwok-Pui;Bik-SanLau,Clara.Structural characterization and immunomodulatory effect of a polysaccharide HCP-2 from Houttuynia cordata,CARBOHYDRATE POLYMERS,2014,103():244-249
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