| Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431 | |
Yang, Yanfang1; Zhao, Hainan2; Barrero, Roberto A.3; Zhang, Baohong4; Sun, Guiling5,6 ; Wilson, Iain W.7; Xie, Fuliang4; Walker, Kevin D.8,9; Parks, Joshua W.10; Bruce, Robert10; Guo, Guangwu11; Chen, Li11; Zhang, Yong12; Huang, Xin13; Tang, Qi14,15; Liu, Hongwei1; Bellgard, Matthew I.3; Qiu, Deyou1; Lai, Jinsheng2; Hoffman, Angela10
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| 2014-01-25 | |
| Source Publication | BMC GENOMICS
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| Volume | 15Issue:1 |
| Abstract | Background: Paclitaxel (Taxol (TM)) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, an endophytic fungus of T. brevifolia. Subsequently, paclitaxel was found in hazel (Corylus avellana L.) and in several other endophytic fungi. The distribution of paclitaxel in plants and endophytic fungi and the reported sequence homology of key genes in paclitaxel biosynthesis between plant and fungi species raises the question about whether the origin of this pathway in these two physically associated groups could have been facilitated by horizontal gene transfer. |
| Keyword | Penicillium Aurantiogriseum Nrrl 62431 Paclitaxel Taxol (Tm) Endophytic Fungi Genome Sequence Horizontal Gene Transfer |
| DOI | 10.1186/1471-2164-15-69 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000332573300001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/18035 |
| Collection | 资源植物与生物技术所级重点实验室 |
| Affiliation | 1.Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Res Inst Forestry, Beijing 100091, Peoples R China 2.China Agr Univ, Coll Agr Biotechnol, Beijing 100094, Peoples R China 3.Murdoch Univ, Ctr Comparat Genom, Perth, WA 6150, Australia 4.E Carolina Univ, Dept Biol, Greenville, NC 27858 USA 5.Southwest Forestry Univ, Sch Life Sci, Kunming 650224, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China 7.CSIRO Plant Ind, Canberra, ACT 2001, Australia 8.Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA 9.Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA 10.Univ Portland, Dept Chem, Portland, OR 97203 USA 11.BGI Shenzhen, Shenzhen 518000, Peoples R China 12.China Agr Univ, Dept Plant Pathol, Beijing 100094, Peoples R China 13.Chinese Acad Inspect & Quarantine, Inst Plant Quarantine, Beijing 100029, Peoples R China 14.Hunan Agr Univ, Hunan Prov Key Lab Crop Germplasm Innovat & Utili, Changsha 410128, Hunan, Peoples R China 15.Hunan Agr Univ, Natl Chinese Med Herbs Hunan Technol Ctr, Changsha 410128, Hunan, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Yanfang,Zhao, Hainan,Barrero, Roberto A.,et al. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431[J]. BMC GENOMICS,2014,15(1). |
| APA | Yang, Yanfang.,Zhao, Hainan.,Barrero, Roberto A..,Zhang, Baohong.,Sun, Guiling.,...&Hoffman, Angela.(2014).Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431.BMC GENOMICS,15(1). |
| MLA | Yang, Yanfang,et al."Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431".BMC GENOMICS 15.1(2014). |
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