Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431
Yang, Yanfang1; Zhao, Hainan2; Barrero, Roberto A.3; Zhang, Baohong4; Sun, Guiling5,6; Wilson, Iain W.7; Xie, Fuliang4; Walker, Kevin D.8,9; Parks, Joshua W.10; Bruce, Robert10; Guo, Guangwu11; Chen, Li11; Zhang, Yong12; Huang, Xin13; Tang, Qi14,15; Liu, Hongwei1; Bellgard, Matthew I.3; Qiu, Deyou1; Lai, Jinsheng2; Hoffman, Angela10
2014-01-25
发表期刊BMC GENOMICS
卷号15期号:1
摘要Background: Paclitaxel (Taxol (TM)) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, an endophytic fungus of T. brevifolia. Subsequently, paclitaxel was found in hazel (Corylus avellana L.) and in several other endophytic fungi. The distribution of paclitaxel in plants and endophytic fungi and the reported sequence homology of key genes in paclitaxel biosynthesis between plant and fungi species raises the question about whether the origin of this pathway in these two physically associated groups could have been facilitated by horizontal gene transfer.
关键词Penicillium Aurantiogriseum Nrrl 62431 Paclitaxel Taxol (Tm) Endophytic Fungi Genome Sequence Horizontal Gene Transfer
DOI10.1186/1471-2164-15-69
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号WOS:000332573300001
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18035
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Res Inst Forestry, Beijing 100091, Peoples R China
2.China Agr Univ, Coll Agr Biotechnol, Beijing 100094, Peoples R China
3.Murdoch Univ, Ctr Comparat Genom, Perth, WA 6150, Australia
4.E Carolina Univ, Dept Biol, Greenville, NC 27858 USA
5.Southwest Forestry Univ, Sch Life Sci, Kunming 650224, Peoples R China
6.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China
7.CSIRO Plant Ind, Canberra, ACT 2001, Australia
8.Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
9.Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA
10.Univ Portland, Dept Chem, Portland, OR 97203 USA
11.BGI Shenzhen, Shenzhen 518000, Peoples R China
12.China Agr Univ, Dept Plant Pathol, Beijing 100094, Peoples R China
13.Chinese Acad Inspect & Quarantine, Inst Plant Quarantine, Beijing 100029, Peoples R China
14.Hunan Agr Univ, Hunan Prov Key Lab Crop Germplasm Innovat & Utili, Changsha 410128, Hunan, Peoples R China
15.Hunan Agr Univ, Natl Chinese Med Herbs Hunan Technol Ctr, Changsha 410128, Hunan, Peoples R China
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Yang, Yanfang,Zhao, Hainan,Barrero, Roberto A.,et al. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431[J]. BMC GENOMICS,2014,15(1).
APA Yang, Yanfang.,Zhao, Hainan.,Barrero, Roberto A..,Zhang, Baohong.,Sun, Guiling.,...&Hoffman, Angela.(2014).Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431.BMC GENOMICS,15(1).
MLA Yang, Yanfang,et al."Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431".BMC GENOMICS 15.1(2014).
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