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题名: (+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
作者: Yan, Yong-Ming1, 4; Ai, Jun3; Shi, Yan-Ni1, 4; Zuo ZhiLi(左之利)1; Hou, Bo1; Luo, Jie1; null(程永现)1, 2
刊名: ORGANIC LETTERS
关键词: DISEASE ; PRODUCTS
英文摘要: (+/-)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-beta 1 (TGF-beta 1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.
出版日期: 2014-01-17
卷号: 16, 期号:2, 页码:532-535
DOI标识: 10.1021/ol403409v
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 1523-7060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17944
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Yan,YongMing;Ai,Jun;Shi,YanNi;Zuo,ZhiLi;Hou,Bo;Luo,Jie;Cheng,YongXian*.(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3,ORGANIC LETTERS,2014,16(2):532-535
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