(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
Yan, Yong-Ming1,4; Ai, Jun3; Shi, Yan-Ni1,4; Zuo, Zhi-Li1; Hou, Bo1; Luo, Jie1; Cheng, Yong-Xian1,2
2014-01-17
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号16期号:2页码:532-535
摘要(+/-)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-beta 1 (TGF-beta 1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.
关键词Disease Products
资助信息National Natural Science Foundation of China [21272241, 21172223]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources
学科领域Chemistry, Organic
DOI10.1021/ol403409v
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000330098400053
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17944
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yan, Yong-Ming,Ai, Jun,Shi, Yan-Ni,et al. (+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3[J]. ORGANIC LETTERS,2014,16(2):532-535.
APA Yan, Yong-Ming.,Ai, Jun.,Shi, Yan-Ni.,Zuo, Zhi-Li.,Hou, Bo.,...&Cheng, Yong-Xian.(2014).(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3.ORGANIC LETTERS,16(2),532-535.
MLA Yan, Yong-Ming,et al."(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3".ORGANIC LETTERS 16.2(2014):532-535.
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