(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
Yan, Yong-Ming1,4; Ai, Jun3; Shi, Yan-Ni1,4; Zuo, Zhi-Li1; Hou, Bo1; Luo, Jie1; Cheng, Yong-Xian1,2
Corresponding AuthorCheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,132 Lanhei Rd,Kunming 650201,Peoples R China. ; yxcheng@mail.kib.ac.cn
2014-01-17
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume16Issue:2Pages:532-535
Abstract(+/-)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-beta 1 (TGF-beta 1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.
KeywordDisease Products
Subject AreaChemistry, Organic
DOI10.1021/ol403409v
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000330098400053
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17944
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yong-Ming,Ai, Jun,Shi, Yan-Ni,et al. (+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3[J]. ORGANIC LETTERS,2014,16(2):532-535.
APA Yan, Yong-Ming.,Ai, Jun.,Shi, Yan-Ni.,Zuo, Zhi-Li.,Hou, Bo.,...&Cheng, Yong-Xian.(2014).(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3.ORGANIC LETTERS,16(2),532-535.
MLA Yan, Yong-Ming,et al."(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3".ORGANIC LETTERS 16.2(2014):532-535.
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