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题名: Nortriterpenoids from Schisandra chinensis and their absolute configurational assignments by electronic circular dichroism study
作者: Shi, Yi-Ming1, 3; Wang, Li-Yan2; Zou, Xi-Sheng1; Li, Xiao-Nian1; Shang, Shan-Zhai1, 3; Gao, Zhong-Hua1, 3; Liang, Cheng-Qin1, 3; null(罗怀容)1; Li, Hong-Lin2; Xiao, Wei-Lie1; null(孙汉董)1
刊名: TETRAHEDRON
关键词: Schisandra ; Schisandra chinensis ; Nortriterpenoid ; Electronic circular dichroism ; Absolute configuration
英文摘要: Twelve new nortriterpenoids, namely wuweizidilactones J-P (1-7), schindilactones I-K (8-10), preschisanartanin N (11), and schisdilactone J (12), as well as 23 known analogues, were isolated from the leaves and stems of Schisandra chinensis. The absolute configurations of 1 and 11 were established by calculated electronic circular dichroism (ECD) spectra and that of 7 was confirmed by single-crystal X-ray diffraction. The absolute configurations of 2-6, 8, and 9 were determined by an empirical comparison of their experimental ECD spectra with that of 1. It is the first time that the ECD spectra of 18(13 -> 14)-abeoschiartane-, 18-norschiartane-, and schisanartane-type nortriterpenoids possessing an alpha,beta-unsaturated-gamma-lactone moiety are presented, this method providing an alternative means of obtaining absolute configurational assignments for these types of nortriterpenoids. All isolates were evaluated for their anti-acetylcholinesterase and anti-butyrylcholinesterase activities, and compounds 8, 13, 23, and 31 show anti-acetylcholinesterase activity at concentrations of 50 mu M, with 12.7, 10.7, 16.6, and 32.1% inhibition, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
出版日期: 2014-01-28
卷号: 70, 期号:4, 页码:859-868
DOI标识: 10.1016/j.tet.2013.12.023
语种: 英语
ISSN号: 0040-4020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17930
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Shi,YiMing;Wang,LiYan;Zou,XiSheng;Li,XiaoNian;Shang,ShanZhai;Gao,ZhongHua;Liang,ChengQin;Luo,HuaiRong;Li,HongLin;Xiao,WeiLie*;Sun,HanDong.Nortriterpenoids from Schisandra chinensis and their absolute configurational assignments by electronic circular dichroism study,TETRAHEDRON,2014,70(4):859-868
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