| Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells | |
| Liu, Zi1,3; Ma, Liang1; Wen, Zhe-Sheng2; Cheng, Yong-Xian4; Zhou, Guang-Biao1 | |
| Corresponding Author | Zhou,GB (reprint author),Chinese Acad Sci,Inst Zool,Div Mol Carcinogenesis & Targeted Therapy Canc,State Key Lab Biomembrane & Membrane Biotechnol,Beijing 100101,Peoples R China. ; gbzhou@ioz.ac.cn |
| 2014-02-01 | |
| Source Publication | ACS MEDICINAL CHEMISTRY LETTERS
 |
| ISSN | 1948-5875 |
| Volume | 5Issue:2Pages:113-118 |
| Abstract | Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is able to stabilize c-Myc oncogenic transcription factor and promote proliferation and transformation of cells. CIP2A is overexpressed in many primary tumors, and pharmacological inactivation of CIP2A is an emerging concept for the development of novel anticancer agents. In this study, we demonstrate that overexpression of CIP2A predicts poor prognosis in lung cancer, and a natural compound, ethoxysanguinarine (ESG), effectively down-regulates CIP2A protein and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. ESG inhibits proliferation and induces apoptosis of lung cancer cells, and enhances the effects of cisplatin on malignant cells. Taken together, our findings demonstrate that CIP2A is inversely associated with the clinical outcome of lung cancer, and ESG can serve as a lead compound for the development of CIP2A inhibitor for cancer therapies. |
| Keyword | Ethoxysanguinarine Cip2a Lung Cancer Cell Proliferation Apoptosis |
| Subject Area | Chemistry, Medicinal |
| DOI | 10.1021/ml400341k |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000331493600003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/17924 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Zool, Div Mol Carcinogenesis & Targeted Therapy Canc, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China 2.Sun Yat Sen Univ, Canc Hosp, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,et al. Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells[J]. ACS MEDICINAL CHEMISTRY LETTERS,2014,5(2):113-118. |
| APA | Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,Cheng, Yong-Xian,&Zhou, Guang-Biao.(2014).Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.ACS MEDICINAL CHEMISTRY LETTERS,5(2),113-118. |
| MLA | Liu, Zi,et al."Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells".ACS MEDICINAL CHEMISTRY LETTERS 5.2(2014):113-118. |
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| File Name/Size | DocType | Version | Access | License | ||
| Liu-2014-Ethoxysangu（415KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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