Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells
Liu, Zi1,3; Ma, Liang1; Wen, Zhe-Sheng2; Cheng, Yong-Xian4; Zhou, Guang-Biao1
Corresponding AuthorZhou,GB (reprint author),Chinese Acad Sci,Inst Zool,Div Mol Carcinogenesis & Targeted Therapy Canc,State Key Lab Biomembrane & Membrane Biotechnol,Beijing 100101,Peoples R China. ;
AbstractCancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is able to stabilize c-Myc oncogenic transcription factor and promote proliferation and transformation of cells. CIP2A is overexpressed in many primary tumors, and pharmacological inactivation of CIP2A is an emerging concept for the development of novel anticancer agents. In this study, we demonstrate that overexpression of CIP2A predicts poor prognosis in lung cancer, and a natural compound, ethoxysanguinarine (ESG), effectively down-regulates CIP2A protein and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. ESG inhibits proliferation and induces apoptosis of lung cancer cells, and enhances the effects of cisplatin on malignant cells. Taken together, our findings demonstrate that CIP2A is inversely associated with the clinical outcome of lung cancer, and ESG can serve as a lead compound for the development of CIP2A inhibitor for cancer therapies.
KeywordEthoxysanguinarine Cip2a Lung Cancer Cell Proliferation Apoptosis
Subject AreaChemistry, Medicinal
Indexed BySCI
WOS IDWOS:000331493600003
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Zool, Div Mol Carcinogenesis & Targeted Therapy Canc, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
2.Sun Yat Sen Univ, Canc Hosp, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,et al. Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells[J]. ACS MEDICINAL CHEMISTRY LETTERS,2014,5(2):113-118.
APA Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,Cheng, Yong-Xian,&Zhou, Guang-Biao.(2014).Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.ACS MEDICINAL CHEMISTRY LETTERS,5(2),113-118.
MLA Liu, Zi,et al."Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells".ACS MEDICINAL CHEMISTRY LETTERS 5.2(2014):113-118.
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