Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells
Liu, Zi1,3; Ma, Liang1; Wen, Zhe-Sheng2; Cheng, Yong-Xian4; Zhou, Guang-Biao1
2014-02-01
发表期刊ACS MEDICINAL CHEMISTRY LETTERS
ISSN1948-5875
卷号5期号:2页码:113-118
摘要Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is able to stabilize c-Myc oncogenic transcription factor and promote proliferation and transformation of cells. CIP2A is overexpressed in many primary tumors, and pharmacological inactivation of CIP2A is an emerging concept for the development of novel anticancer agents. In this study, we demonstrate that overexpression of CIP2A predicts poor prognosis in lung cancer, and a natural compound, ethoxysanguinarine (ESG), effectively down-regulates CIP2A protein and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. ESG inhibits proliferation and induces apoptosis of lung cancer cells, and enhances the effects of cisplatin on malignant cells. Taken together, our findings demonstrate that CIP2A is inversely associated with the clinical outcome of lung cancer, and ESG can serve as a lead compound for the development of CIP2A inhibitor for cancer therapies.
关键词Ethoxysanguinarine Cip2a Lung Cancer Cell Proliferation Apoptosis
资助信息National Key Program for Basic Research [2012CB910800, 2010CB529201]; National Natural Science Foundation [81071930, 81171925, 81201577]; Special Foundation of President; Strategic Leading Science & Technology Programme of the Chinese Academy of Sciences
学科领域Chemistry, Medicinal
DOI10.1021/ml400341k
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000331493600003
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17924
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Inst Zool, Div Mol Carcinogenesis & Targeted Therapy Canc, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
2.Sun Yat Sen Univ, Canc Hosp, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,et al. Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells[J]. ACS MEDICINAL CHEMISTRY LETTERS,2014,5(2):113-118.
APA Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,Cheng, Yong-Xian,&Zhou, Guang-Biao.(2014).Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.ACS MEDICINAL CHEMISTRY LETTERS,5(2),113-118.
MLA Liu, Zi,et al."Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells".ACS MEDICINAL CHEMISTRY LETTERS 5.2(2014):113-118.
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