| Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells | |
| Liu, Zi1,3; Ma, Liang1; Wen, Zhe-Sheng2; Cheng, Yong-Xian4; Zhou, Guang-Biao1 | |
| 通讯作者 | Zhou,GB (reprint author),Chinese Acad Sci,Inst Zool,Div Mol Carcinogenesis & Targeted Therapy Canc,State Key Lab Biomembrane & Membrane Biotechnol,Beijing 100101,Peoples R China. ; gbzhou@ioz.ac.cn |
| 2014-02-01 | |
| 发表期刊 | ACS MEDICINAL CHEMISTRY LETTERS
 |
| ISSN | 1948-5875 |
| 卷号 | 5期号:2页码:113-118 |
| 摘要 | Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is able to stabilize c-Myc oncogenic transcription factor and promote proliferation and transformation of cells. CIP2A is overexpressed in many primary tumors, and pharmacological inactivation of CIP2A is an emerging concept for the development of novel anticancer agents. In this study, we demonstrate that overexpression of CIP2A predicts poor prognosis in lung cancer, and a natural compound, ethoxysanguinarine (ESG), effectively down-regulates CIP2A protein and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. ESG inhibits proliferation and induces apoptosis of lung cancer cells, and enhances the effects of cisplatin on malignant cells. Taken together, our findings demonstrate that CIP2A is inversely associated with the clinical outcome of lung cancer, and ESG can serve as a lead compound for the development of CIP2A inhibitor for cancer therapies. |
| 关键词 | Ethoxysanguinarine Cip2a Lung Cancer Cell Proliferation Apoptosis |
| 学科领域 | Chemistry, Medicinal |
| DOI | 10.1021/ml400341k |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331493600003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17924 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, Div Mol Carcinogenesis & Targeted Therapy Canc, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China 2.Sun Yat Sen Univ, Canc Hosp, Dept Thorac Surg, Guangzhou 510080, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,et al. Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells[J]. ACS MEDICINAL CHEMISTRY LETTERS,2014,5(2):113-118. |
| APA | Liu, Zi,Ma, Liang,Wen, Zhe-Sheng,Cheng, Yong-Xian,&Zhou, Guang-Biao.(2014).Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.ACS MEDICINAL CHEMISTRY LETTERS,5(2),113-118. |
| MLA | Liu, Zi,et al."Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells".ACS MEDICINAL CHEMISTRY LETTERS 5.2(2014):113-118. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Liu-2014-Ethoxysangu（415KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论